Abstract:Most living organisms encode an ensemble of protein transporters and chaperones to regulate copper levels. The ycn operon of the bacterium Bacillus subtilisis regulated in response to copper, suggesting that the three proteins it encodes may engage in direct interactions with copper ions to facilitate transport and homeostasis of this transition metal. Here, we use a combination of structural, biochemical, biophysical, and bioinorganic approaches to determine the structures of individual proteins and their int… Show more
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