Structural studies and macro-performances of hydroxyapatite-reinforced keratin thin films for biological applications

Tu, Huang; Yu, Weidong; Duan, Ling

doi:10.1007/s10853-016-0140-0

Cited by 15 publications

(21 citation statements)

References 42 publications

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“…One method is to blend keratin with other kinds of polymers such that the deficiency of keratin materials can be compensated for by the excellent mechanical properties of the added polymers. However, the addition of polymers is often excessive and the final products are not considered pure keratin materials [12,13,14]. The other method is that the keratin is physically or chemically modified.…”

Section: Introductionmentioning

confidence: 99%

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Yang

Niu

et al. 2018

Polymers

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Much research has focused on improvement of the structural and mechanical properties of regenerated keratin materials by physical or chemical methods in recent years. In this research, regenerated keratin materials were modified with graphene oxide (GO). The properties of modified keratin films and the mechanism of interaction between GO and keratin macromolecules were studied. The SEM and XRD test results showed that the orientation of keratin macromolecules could be effectively improved by GO, which favored improvement of the keratin material’s crystallinity and made the films more uniform and compact. The thermal stability and mechanical properties of GO-modified keratin films were also improved significantly. At the same time, the reaction mechanism between keratin and GO materials was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), FT-IR, and Raman spectroscopy. It was shown that there was no chemical reaction between GO and keratin molecules, and the interaction between them was mainly via hydrogen bonding and van der Waals forces.

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Section: Introductionmentioning

confidence: 99%

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Yang

Niu

et al. 2018

Polymers

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“…The disulfide bonds in cystine form a three-dimensionally linked network together with salt type bonds and hydrogen bonding. 9,10 It is well known that disulfide bonds have great bonding energy, making keratin's secondary structure difficult to damage easily, 11 so the wool fiber has higher stability and lower solubility. How to effectively break the disulfide bonds in the dissolving process while at the same time ensuring the protein macromolecule structure is not damaged or degraded too much is the key to obtaining high molecular weight keratin solution.…”

mentioning

confidence: 99%

Study on the effect of organic phosphonic compounds on disulfide bonds in wool

Yang

Niu

et al. 2018

Textile Research Journal

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In this study a new type of organic phosphonic compound named LKS-610, a kind of reducing agent, was used to cleave disulfide bonds in wool fibers. Research into the extraction of keratin from wool and processing into useful textile materials is a hot topic in the field of textiles. Wool fibers are rich in disulfide bonds which are the main chemical crosslinkage to maintain the fiber's secondary structure. If the disulfide bonds between molecular chains can be sufficiently disrupted, it will facilitate to obtain the keratin solution suitable for the regenerated materials preparation. The reaction mechanism and effect were analyzed through scanning electron microscopic test (SEM), X-ray photoelectron spectroscopy test (XPS) and amino acid content test. After a period of processing time, the valence state of sulfur element on fiber surface changed significantly; this result shows that the disulfide bonds reacted with LKS-610 reagent and generated thiol groups. Amino acid analysis demonstrated that for wool fibers treated for 60 min at 80 C, the quality percentage of cystine in wool was reduced from 10.09% to 1.05%, the majority of disulfide bonds had been cleaved. In this case, fiber scales were almost completely stripped and the cortical layer was not significantly damaged but became prone to swelling. This indicated that LKS-610 reagent could disrupt the disulfide bonds in the wool thoroughly and efficiently, and reduce these bonds to thiol groups. Wool fibers pretreated by LKS-610 reagent can be dissolved readily to prepare keratin solution; this keratin solution with high dissolution ratio and large molecular weight can be used in research into modification and preparation of regenerated protein materials.

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“…It is the main component of materials such as hair, fur, wool, nails, hooves, or claws; however, several years ago it was experimentally combined with bioactive ceramics to determine the potential use of such formed material in the regeneration of the skeletal system [ 270 ]. Two-component systems using keratin and hydroxyapatite have been used to produce membranes [ 271 ], porous scaffolds [ 272 ], and laminar and reinforced keratin/HAp scaffolds [ 273 ]. However, in 2017, Arslan et al [ 274 ] presented a very cost-effective method of obtaining keratin from human hair (from a local hairdresser after obtaining ethical permission for its use), hydroxyapatite from egg shells, and collagen from the jellyfish Rhizostoma pulmo .…”

Section: Conjugates For Drug Deliverymentioning

confidence: 99%

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

et al. 2021

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Regenerative medicine is becoming a rapidly evolving technique in today’s biomedical progress scenario. Scientists around the world suggest the use of naturally synthesized biomaterials to repair and heal damaged cells. Hydroxyapatite (HAp) has the potential to replace drugs in biomedical engineering and regenerative drugs. HAp is easily biodegradable, biocompatible, and correlated with macromolecules, which facilitates their incorporation into inorganic materials. This review article provides extensive knowledge on HAp and collagen-containing compositions modified with drugs, bioactive components, metals, and selected nanoparticles. Such compositions consisting of HAp and collagen modified with various additives are used in a variety of biomedical applications such as bone tissue engineering, vascular transplantation, cartilage, and other implantable biomedical devices.

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Structural studies and macro-performances of hydroxyapatite-reinforced keratin thin films for biological applications

Cited by 15 publications

References 42 publications

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Study on the effect of organic phosphonic compounds on disulfide bonds in wool

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

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