Structural Strength Analyses for Low Brass Filler Biomaterial with Anti-Trauma Effects in Articular Cartilage Scaffold Design

Miskon, Azizi; Zaidi, Ahmad Mujahid Ahmad

doi:10.3390/ma15134446

Cited by 14 publications

(6 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, our X-ray diffraction (XRD) tests [ 74 ] for CuZn powder found that the results were coincidently similar to those of Nogueira et al (2022) [ 75 ], as shown on the left of Figure 2 with the blue colour lines and black colour dots, respectively. The XRD test found two main peaks at two similar diffraction angles of 2θ degrees, indicating the CuZn and Cu 5 Zn 8 phases.…”

Section: Other Stimuli and Chemotherapiessupporting

confidence: 86%

See 1 more Smart Citation

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

Self Cite

View full text Add to dashboard Cite

This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

show abstract

Section: Other Stimuli and Chemotherapiessupporting

confidence: 86%

“… XRD intensity against diffraction angle of 2θ for CuZn (left) [ 74 , 75 ] and illustration of Cu-bonded polyester urethane via N (right) [ 54 ]. Reprinted with permission.…”

Section: Figurementioning

confidence: 99%

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scientists and clinicians have attempted to solve these problems for the past thirty years [20], but 30% of OS patients still do not respond to these standard treatments [21]. Therefore, combinational and targeted therapies [22] [23] are developed for these problems and has a higher response rate [24]. However, their evidence of efficacy, long-term use [25], and personalised precision medicine [26] remain inadequate [27].…”

Section: Of 26mentioning

confidence: 99%

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

Zaidi¹,

Haque²,

Miskon³

2023

Preprint

View full text Add to dashboard Cite

There has been no significant efficacy in treatment for osteosarcoma (OS) metastasis after nearly four decades of trials. This motivates us to elucidate OS therapies according to their four bidirectional mutation stages. To refresh the OS therapy status quo, the historical developments and clinical advancements are briefly described. However, the main issue of metastasis remains unresolved, accounting for 90% of pulmonary metastasis deaths. Thus, this metastasis problem is related to immune evasion and chemoresistance that are being induced after long-term treatment by the use of immunotherapy for tumorigenesis. Therefore, it is rationale to discuss the relationship cycles of mutation stages including tumorigenesis, metastasis, immune evasion, and chemoresistance. Even though many combinational and targeted therapies have been developed to intensify these mutation treatments, successful clinical translations with higher cure rates are still rare. Through this review, an in-depth understanding of the bidirectional relationship between the four OS mutation stages and their respective therapies is provided. Herein, we summarise the medicines used to treat tumorigenesis, including COLGALT2 inhibitors, Tra2B, and AGAP1, miR-148a and miR-21-5p EVs, and the lncRNA LIFR-AS1. Following the medicines used to treat metastasis are AXL, miR-135a-5p, mRNA BCL6, TGFβ1, Tim-3, SOCS5, CASC15, KLF3-AS1, PDCD4, ATG5, and Rab22a-NeoF1. Then the medicines used to treat immune evasion are N-cadherin, anti-IL-9, USP12 inhibitor, IgG-4+ B-cells, LAP inhibitor, anti-Wnt2 mAb, anti-αvβ8 integrin, HK2-mediated IκBα, IDO inhibitor with NO, and TGF-βRII with anti-IgG1. Finally, the medicines used to treat chemoresistance are DHFR, FPGS, HSP-90AA1, XCT-790, ATKI, and IGF1. As a result, this contribution is expected to serve as a reference and guide for scientists and clinicians.

show abstract

“…Extensive research on the mechanical and microstructural properties of widely used cast, wrought, or hot-forged CoCrMo alloys has been reported [ 6 , 12 , 13 , 14 , 15 ]. To fulfill the criteria for metallic materials as feasible implants, it is important to reduce the stress shielding effect and enhance osseointegration [ 16 , 17 , 18 , 19 , 20 , 21 ] by applying porous lattice structures, which are difficult to achieve via traditional fabrication processes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Porosity and Heat Treatment on Mechanical Properties of Additive Manufactured CoCrMo Alloys

et al. 2023

View full text Add to dashboard Cite

To minimize the stress shielding effect of metallic biomaterials in mimicking bone, the body-centered cubic (bcc) unit cell-based porous CoCrMo alloys with different, designed volume porosities of 20, 40, 60, and 80% were produced via a selective laser melting (SLM) process. A heat treatment process consisting of solution annealing and aging was applied to increase the volume fraction of an ε-hexagonal close-packed (hcp) structure for better mechanical response and stability. In the present study, we investigated the impact of different, designed volume porosities on the compressive mechanical properties in as-built and heat-treated CoCrMo alloys. The elastic modulus and yield strength in both conditions were dramatically decreased with increasing designed volume porosity. The elastic modulus and yield strength of the CoCrMo alloys with a designed volume porosity of 80% exhibited the closest match to those of bone tissue. Different strengthening mechanisms were quantified to determine their contributing roles to the measured yield strength in both conditions. The experimental results of the relative elastic modulus and yield strength were compared to the analytical and simulation modeling analyses. The Gibson–Ashby theoretical model was established to predict the deformation behaviors of the lattice CoCrMo structures.

show abstract

Structural Strength Analyses for Low Brass Filler Biomaterial with Anti-Trauma Effects in Articular Cartilage Scaffold Design

Cited by 14 publications

References 75 publications

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

Effect of Porosity and Heat Treatment on Mechanical Properties of Additive Manufactured CoCrMo Alloys

Contact Info

Product

Resources

About