Structural, stability, magnetic, and toxicity studies of nanocrystalline iron oxide and cobalt ferrites for biomedical applications

Peeples, B.; Goornavar, Virupaxi; Peeples, Caryn; Spence, D.; Parker, V. B.; Bell, Crystal; Biswal, Dibyajyoti; Ramesh, Govindarajan T.; Pradhan, A. K.

doi:10.1007/s11051-014-2290-9

Cited by 35 publications

(14 citation statements)

References 13 publications

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“…Despite the promising properties of this material, its use in biomedical application is debated due to the presence of cobalt. While for uncoated cobalt ferrite NPs a non-negligible toxicity is reported in the literature [13,14], the coating with silica or polymers strongly improves their biocompatibility [13,15,16]. However, a low residual toxicity is often still present, depending on the cellular line investigated and on the concentration of the NPs used [17,18].…”

Section: Introductionmentioning

confidence: 99%

Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles

Fantechi

Innocenti

Albino

et al. 2015

Journal of Magnetism and Magnetic Materials

107

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Section: Introductionmentioning

confidence: 99%

Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles

Fantechi

Innocenti

Albino

et al. 2015

Journal of Magnetism and Magnetic Materials

107

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“…[8][9][10] Moreover, these processes mostly end up with hydrophobic nanoparticles (NPs), which are often subjected to surface engineering, making them water dispersible. [11][12][13] The absorption of NPs produced by hydrophobic polymers is greater than that of NPs produced by hydrophilic polymers. 14,15 However, hydrophobic NPs may induce genotoxicity, carcinogenicity, and teratogenicity; therefore, a hydrophilic surface is preferred over the hydrophobic surface for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, <em>T</em><sub>2</sub> relaxometry, and photodynamic treatment potential

Bano¹,

Nazir²,

Nazir³

et al. 2016

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have the potential to be used as multimodal imaging and cancer therapy agents due to their excellent magnetism and ability to generate reactive oxygen species when exposed to light. We report the synthesis of highly biocompatible SPIONs through a facile green approach using fruit peel extracts as the biogenic reductant. This green synthesis protocol involves the stabilization of SPIONs through coordination of different phytochemicals. The SPIONs were functionalized with polyethylene glycol (PEG)-6000 and succinic acid and were extensively characterized by X-ray diffraction analysis, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, Rutherford backscattering spectrometry, diffused reflectance spectroscopy, fluorescence emission, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, and magnetization analysis. The developed SPIONs were found to be stable, almost spherical with a size range of 17–25 nm. They exhibited excellent water dispersibility, colloidal stability, and relatively high R 2 relaxivity (225 mM −1 s −1 ). Cell viability assay data revealed that PEGylation or carboxylation appears to significantly shield the surface of the particles but does not lead to improved cytocompatibility. A highly significant increase of reactive oxygen species in light-exposed samples was found to play an important role in the photokilling of human cervical epithelial malignant carcinoma (HeLa) cells. The bio-SPIONs developed are highly favorable for various biomedical applications without risking interference from potentially toxic reagents.

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“…Magnetic nanoparticles have attracted much attentions in research because of their wide range of applications in data storage [1][2][3], magneto-optical devices [4], catalysis [5], biomedical applications like drug delivery [6], magnetic resonance imaging [6] [7], biosensors[8] and hyperthermia [9][10][11][12]. These nanoparticles show very interesting physical properties due to their reduced size compared to their bulk counterpart.…”

Section: Introductionmentioning

confidence: 99%

“…Grains of different sizes have different anisotropies and H C . Due to the increase in anisotropy at low temperature, the intergranular interactions11 are weakened at 10 K, i.e. anisotropy dominates over intergranular interactions.…”

mentioning

confidence: 99%

Exchange spring like magnetic behavior in cobalt ferrite nanoparticles

Chithra

Anumol

Sahu

et al. 2016

Journal of Magnetism and Magnetic Materials

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Structural, stability, magnetic, and toxicity studies of nanocrystalline iron oxide and cobalt ferrites for biomedical applications

Cited by 35 publications

References 13 publications

Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles

Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, <em>T</em><sub>2</sub> relaxometry, and photodynamic treatment potential

Exchange spring like magnetic behavior in cobalt ferrite nanoparticles

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