Structural, spectral, cytotoxic and biocatalytic studies of a dinuclear phenoxo bridged Zn(II) complex from NNO donor tridentate Schiff base

Jayendran, Manjari; Kurup, M.R. Prathapachandra

doi:10.1016/j.cdc.2022.100853

Cited by 3 publications

(2 citation statements)

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“…The highly stable complexes formed by SBs with transition metals often lead to compounds with strongly enhanced activities in inorganic [22,23] and bioinorganic chemistry [24], materials science [25], and pharmacology for biomedical applications [26][27][28][29][30]. The most described biological activities regarding the SBs complexes are antitumoral [31][32][33][34][35], antioxidant [36,37], antidiabetic [38][39][40][41], antimalarial [42], antiarthritic [43], antimicrobial [44][45][46][47][48], neuroprotective, catalase-like and catecholase-like enzymatic [49,50], and DNA-binding [51,52]. Recently, Aggarwal et al (2022) [53] underlined the potential applicability of some SBs and their metal complexes for the treatment of COVID-19 [54], which may represent valid alternatives to the classic treatments for this disease [55,56].…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Iacopetta,

Ceramella,

Catalano

et al. 2023

Inorganics

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Complexes of Schiff bases (SBs) with metals are promising compounds exhibiting a broad range of applications, such as catalysts, polymers, dyes, and several biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic actions. Considering the crisis that the whole world is now facing against antimicrobial-resistant bacteria, in the present review, we chose to focus on the activity of SBs as antimicrobials, particularly underlying the most recent studies in this field. Finally, some interesting catalytic applications recently described for metal complexes with SBs have also been discussed.

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Section: Introductionmentioning

confidence: 99%

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Iacopetta,

Ceramella,

Catalano

et al. 2023

Inorganics

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“…A wide variety of organic compounds with original structures and topologies are used as chelating ligands in the synthesis of a wide variety of metal complexes [10][11][12]. They are able to coordinate one or more metal atoms through the nitrogen of azomethine and other functional groups provided by the precursors of these Schiff bases [13,14]. The coordination geometries of such complexes depend on the nature of the ligand, the number and type of donor atoms, the configuration, and the chain length between the coordination sites [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Characterization, and X-Ray Crystal Structure of a 1:1 Co-Crystal of bis{bis[((2-(1H-imidazol-2-yl)methylidene)amino)phenolato-κ3N,N’,O]nickel(II)} and bis{bis[((2-(1H-imidazol-2-yl)methylidene) amino)phenol-κ3N,N’,O]nickel(II)} tetra(chloride)

Diop

Seck

Thiam

et al. 2022

EJCS

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The present investigation describes the synthesis and structural study of the ligand 2-((1H-imidazol-2-yl)methyleneamino)phenol, which was used to generate three dimensio-nal supramolecular complex formulated as {[Ni(HL)2]2.[Ni(H2L)2]2.(Cl)4.(H2O)5}. The title compound crystallizes in the orthorhombic space group Fddd with the following unit cell parameters: a = 13.9269(4) Å, b = 29.5295(16) Å, c = 43.1739(15) Å, V = 17755.5(12) Å3, Z = 8, R1 = 0.043 and wR2 = 0.129. For this compound, the structure reveals that one neutral mononuclear unit [Ni(HL)2] and one cationic mononuclear unit [Ni(H2L)2]2+. In the neutral unit, the organic molecule acts as a tridentate through one imino nitrogen atom, one nitrogen atom from the imidazole ring and one phenolate oxygen atom. In the cationic unit, it acts as tridentate through one imino nitrogen atom, one nitrogen atom from the imidazole ring and one oxygen atom of non-deprotonated phenol group. In both units the nickel(II) ion is hexacoordinated and the coordination environment can be described as distorted octahedral geometry. Numerous hydrogen bonds link the molecules into three dimensional network.

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Unconventional Dual Donor-Acceptor Topologies of Aromatic Rings in Amine-Based Polymeric Tetrahedral Zn(II) Compounds Involving Unusual Non-Covalent Contacts: Antiproliferative Evaluation and Theoretical Studies

et al. 2023

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Two Zn(II) coordination polymers, viz., [Zn2Cl2(H2O)2(µ-4-AmBz)2]n (1) and [ZnCl2(µ-3-AmPy)2]n (2) (4-AmBz = 4-aminobenzoate, 3-AmPy = 3-aminopyridine) have been prepared at room temperature and characterized using elemental analysis, FT-IR, electronic spectroscopy, TGA (thermogravimetric analysis) and single crystal XRD. Crystal structure analyses of the polymers unfold the presence of non-covalent anion–π, π-stacking and unusual NH2(amino)⋯π interactions which provide rigidity to the crystal structures. Unconventional Type I Cl⋯Cl interactions also play a pivotal role in the stability of compound 1. Molecular electrostatic potential (MEP) surface analysis reveals that the MEP values over the center of the aromatic rings of coordinated 4-AmBz and 3-AmPy moieties are positive on one side and negative on the other side which confirms the dual non-covalent donor-acceptor topologies of the aromatic rings and explains the concurrent formation of unusual non-covalent NH2···π and anion–π interactions. DFT (density functional theory) calculations, QTAIM (quantum theory of atoms in molecules) and NCI plot (non-covalent index) index analyses reveal that among various non-covalent contacts involved in the crystal packing of the compounds, H-bonds in compound 1 and π-interactions (NH2···π, π-π, anion–π) in compound 2 are energetically significant. We have explored in vitro cytotoxic potential of the compounds in Dalton’s lymphoma (DL) cancer cells using trypan blue and apoptosis assays. The studies show that compounds 1 and 2 can significantly exhibit cytotoxicity in DL cells with minimum cytotoxicity in healthy PBMC cells. Molecular docking studies reveal that the compounds effectively bind with the antiapoptotic target proteins; thereby establishing a structure activity relationship of the compounds.

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Structural, spectral, cytotoxic and biocatalytic studies of a dinuclear phenoxo bridged Zn(II) complex from NNO donor tridentate Schiff base

Cited by 3 publications

References 42 publications

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Syntheses, Characterization, and X-Ray Crystal Structure of a 1:1 Co-Crystal of bis{bis[((2-(1H-imidazol-2-yl)methylidene)amino)phenolato-κ3N,N’,O]nickel(II)} and bis{bis[((2-(1H-imidazol-2-yl)methylidene) amino)phenol-κ3N,N’,O]nickel(II)} tetra(chloride)

Unconventional Dual Donor-Acceptor Topologies of Aromatic Rings in Amine-Based Polymeric Tetrahedral Zn(II) Compounds Involving Unusual Non-Covalent Contacts: Antiproliferative Evaluation and Theoretical Studies

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