Structural remodeling secondary to functional remodeling in advanced-stage peripheral facial neuritis

Ma, Jie; Hua, Xu‐Yun; Zheng, Mou‐Xiong; Wu, Jiajia; Huo, Bei‐Bei; Xing, Xiang‐Xin; Ding, Wei; Xu, Jian‐Guang

doi:10.1007/s10072-020-04325-5

Cited by 6 publications

(5 citation statements)

References 49 publications

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“…The orbital MFG is in the prefrontal cortex region of the frontal lobes. Altered VMHC values in the orbital MFG bilaterally were found in peripheral facial neuritis [ 27 ], obsessive-compulsive disorder [ 28 ], internet gaming disorder [ 29 ], and epilepsy [ 30 ]. While in TBI patients, our data suggested that decreased VMHC in the orbital MFG can distinguish chronic TBI from the healthy controls with AUC up to 93.9%.…”

Section: Discussionmentioning

confidence: 99%

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Song

Han

et al. 2022

BioMed Research International

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Objective. To explore the interhemispheric functional coordination following traumatic brain injury (TBI) and its association with posttraumatic anxiety and depressive symptoms. Methods. This was a combination of a retrospective cohort study and a cross-sectional observational study. We investigated the functional coordination between hemispheres by voxel-mirrored homotopic connectivity (VMHC). Grey matter volumes were examined by voxel-based morphometry (VBM), and microstructural integrity of the corpus callosum (CC) was assessed by diffusion tension imaging (DTI). The anxiety and depressive symptoms were evaluated with the Hospital Anxiety and Depression Scale. Results. The VMHC values of the bilateral middle temporal gyrus (MTG) and orbital middle frontal gyrus (MFG) were significantly decreased in TBI patients versus the healthy controls. Weakened homotopic functional connectivity (FC) in the bilateral orbital MFG is moderate positively correlated with anxiety and depressive symptoms. The white matter integrity in the CC was extensively reduced in TBI patients. In the receiver operating characteristic analysis, the VMHC value of the orbital MFG could distinguish TBI from HC with an area under the curve of 0.939 (sensitivity of 1 and specificity of 0.867). Conclusion. TBI disrupts the interhemispheric functional and structural connection, which is correlated with posttraumatic mood disorders. These findings may serve as a clinical indicator for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Song

Han

et al. 2022

BioMed Research International

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“…In recent years, cortical plasticity in PFPS has been extensively discussed (33,34). To date, most work has attempted to identify neuro markers that reveal mechanisms and neurophysiological processes that are significant in PFPS (9,35). Considering that the experience of synkinesis has diverse influences, from a deficit in control to social context, neuro marker candidates will be found to reflect all aspects of involuntary movements in all contexts and help to afford clinical prognostic indicators (36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Alteration of spatial patterns at the network-level in facial synkinesis: an independent component and connectome analysis

Ma¹,

Lu²,

Wu³

et al. 2021

Ann Transl Med

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Background: The treatment of post-facial palsy synkinesis (PFPS) remains inadequate. Previous studies have confirmed that brain plasticity is involved in the process of functional restoration. Isolated activation has been well studied, however, the brain works as an integrity of several isolated regions. This study aimed to assess the alteration of the brain network topology with overall and local characteristics of information dissemination. Understanding the neural mechanisms of PFPS could help to improve therapy options and prognosis.Methods: Patients with facial synkinesis and healthy controls (HCs) were estimated using functional magnetic resonance imaging (fMRI) of resting-state. Subsequently, an independent component analysis (ICA) was used to extract four subnets from the whole brain. Then we used the measurements of graph theory and calculated in the whole-brain network and each sub-network.Results: We found no significant difference between the patient group and the HCs on the wholebrain scale. Then we identified four subnetworks from the resting-state data. In the sub-network property analysis, patients' locally distributed properties in the sensorimotor network (SMN) and ventral default mode network (vDMN) were reduced. It revealed that γ (10,000 permutations, P=0.048) and S (10,000 permutations, P=0.022) within the SMN progressively decreased in patients with PFPS. For the analysis of vDMN, significant differences were found in γ (10,000 permutations, P=0.019), Elocal (10,000 permutations, P=0.008), and β (10,000 permutations, P=0.011) between the groups.Conclusions: Our results demonstrated a reduction in local network processing efficiency in patients with PFPS. Therefore, we speculate that decreased characteristics in the intra-vDMN and intra-SMN, rather than the whole-brain network, may serve distinct symptoms such as facial nerve damage or more synkinetic movements. This finding of the alteration of network properties is a small step forward to help uncover the underlying mechanism.

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“…Diffusion-weighted images were assessed for quality and then further processed using the FSL Diffusion Toolbox (University of Oxford Center for Functional MRI of the Brain, http://www.fmrib.ox.ac.uk/ ). Data processing was performed as described in our previous study ( Ma et al, 2020 ). For a better assessment, diffusivity maps (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)) were assessed.…”

Section: Methodsmentioning

confidence: 99%

“…Two-sample t- test was performed to assess differences between groups (two-tailed) in DTI data. The TBSS statistical method was the same as that described in our previous study ( Ma et al, 2020 ), and the family-wise error correction was used for multiple comparisons ( p < 0.05) ( Hua et al, 2008 ). All numerical values were analyzed using SPSS, and statistical significance was set at p < 0.05.…”

Section: Methodsmentioning

confidence: 99%

Alterations in brain structure and function in patients with osteonecrosis of the femoral head: a multimodal MRI study

Hua

et al. 2021

PeerJ

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Background Pain, a major symptom of osteonecrosis of the femoral head (ONFH), is a complex sensory and emotional experience that presents therapeutic challenges. Pain can cause neuroplastic changes at the cortical level, leading to central sensitization and difficulties with curative treatments; however, whether changes in structural and functional plasticity occur in patients with ONFH remains unclear. Methods A total of 23 ONFH inpatients who did not undergo surgery (14 males, nine females; aged 55.61 ± 13.79 years) and 20 controls (12 males, eight females; aged 47.25 ± 19.35 years) were enrolled. Functional indices of the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and a structural index of tract-based spatial statistics (TBSS) were calculated for each participant. The probability distribution of fiber direction was determined according to the ALFF results. Results ONFH patients demonstrated increased ALFF in the bilateral dorsolateral superior frontal gyrus, right medial superior frontal gyrus, right middle frontal gyrus, and right supplementary motor area. In contrast, ONFH patients showed decreased ReHo in the left superior parietal gyrus and right inferior temporal gyrus. There were no significant differences in TBSS or probabilistic tractography. Conclusion These results indicate cerebral pain processing in ONFH patients. It is advantageous to use functional magnetic resonance imaging to better understand pain pathogenesis and identify new therapeutic targets in ONFH patients.

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Structural remodeling secondary to functional remodeling in advanced-stage peripheral facial neuritis

Cited by 6 publications

References 49 publications

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury

Alteration of spatial patterns at the network-level in facial synkinesis: an independent component and connectome analysis

Alterations in brain structure and function in patients with osteonecrosis of the femoral head: a multimodal MRI study

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