Structural Proteins | Crystallins of the Mammalian Eye Lens

Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

“…We suggested previously (104,120,125), and others (203) have similarly speculated recently, an alternative hypothesis regarding the role of lens protein PTMs in lens transparency and optical function. When crystallin PTMs were first being identified, those associated with normal aging were included with those associated with cataracts (123,129,130).…”

“…Even before birth (121)(122)(123), lens proteins start to accumulate PTMs (124)(125)(126). In 1942, G.L.…”