Structural properties of hydroxyapatite obtained by mechanosynthesis

Silva, C.C.; Pinheiro, A. G.; Miranda, M. A. R.; Góes, J.C.; Sombra, A. S. B.

doi:10.1016/s1293-2558(03)00035-9

Cited by 123 publications

(84 citation statements)

References 27 publications

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“…The mechanical milling is attempted on an objective to synthesize hydroxyapatite phase based on the reaction as follows 5Ca(OH) 2 The planetary ball mill is performed to induce mechanical effect using a powder to ball mass ratio as 1/6 for 15 hours of running and stopping with three different speeds; 170, 270 and 370 rpm. Sintering is then given on the as-milled powders for different high temperatures 1150, 1250 and 1350˚C for 2 hours with 5˚C/min heating and cooling rates.…”

Section: Methodsmentioning

confidence: 99%

“…Mechanical factor has been greatly involved in many synthesis processes where mechanical strength is as success key of phase transformation and chemical reactivity. In ceramic fields, the mechanical milling was proven successful to drive a chemical reaction to synthesize HA from calcium and phosphorus precursors either in dry [1,2] or wet method [3][4][5]. Prolonged mechanical milling has induced amorphous phase transforming from β-TCP (tricalcium phosphate) that makes the new phase more soluble than the source phase and more feasible to produce biphasic phase containing β-TCP and HA after aging in a solution [6].…”

Section: Introductionmentioning

confidence: 99%

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Thermal Analysis on Hydroxyapatite Synthesis through Mechanochemical Method

et al. 2011

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Abstract-Thermal analysis of hydroxyapatite formation through dry mechanochemical method has been studied. The calcium phosphate was synthesized using calcium hydroxide and di-ammonium hydrogen phosphate as the precursors. The ball milling of 1/6 ball-powder mass ratio was employed on mixtures of calcium hydroxide and di-ammonium hydrogen phosphate in three different speeds 170, 270 and 370 rpm for 15 h. As ball-milled powders were then sintered at 1150, 1250 and 1350 o C for 2 h, then subjected to TGA, XRD and FTIR for phase characterization. Calcium phosphates with ammonium are phases of the material. The ammonium is trace of phosphorus precursor. Choosing condition of the process and type of precursors determines type of reactions and its products.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermal Analysis on Hydroxyapatite Synthesis through Mechanochemical Method

et al. 2011

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“…Besides, mechanochemical treatment has been recently receiving attention as an alternative route in preparing materials characterized by better biocompatibility with natural bone [18,19]. Since then, there are several studies using a wet medium in mechanical milling have been reported [20][21][22] instead of milling in dry condition [18,23]. In this present study, HA powder was prepared through mechanochemical route without using any wet medium.…”

Section: Introductionmentioning

confidence: 98%

Synthesis of Hydroxyapatite through Dry Mechanochemical Method and Its Conversion to Dense Bodies: Preliminary Result

2011

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“…Mechanical activation (MA) as a solid-state reaction has been widely studied as an appropriate technique to produce nano-structured HA [6][7][8][9] and carbonate substituted HA [10][11][12]. Solid-state reactions usually give a stoichiometric and well-crystallized product [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Solid-state reactions usually give a stoichiometric and well-crystallized product [6][7][8][9][10][11][12]. Sol-gel rout, which is one of the wet chemical methods for the preparation of HA nanopowder, has a low fabrication rate but can produce products with high purity and nano-sized particles [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and bioactivity evaluation of nano-structured hydroxyapatite

Fathi¹,

Mortazavi²,

Hanifi³

et al. 2009

Computational Methods and Experiments in Materials Characterisation IV

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Due to its biocompatibility and bioactivity, hydroxyapatite (HA) has a wide range of applications in medical engineering cases, such as bone repair and bone tissue regeneration. The use of artificial HA with a similar structure and chemical composition to biological apatite could increase the durability of the HA inside the natural hard tissues. The aim of the present work was to synthesis nano-structured HA via different routs, the comparison of their characteristics and enhancement of the bioactivity of HA by controlling its crystallite size and chemical composition. Nano HA was prepared by mechanical activation and sol gel routs. The x-ray diffraction technique (XRD), Fourier transform infra red spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to characterize the HA powder. The synthesized powder was soaked in simulated body fluid (SBF) for various periods of time in order to evaluate its bioresorbability and bioactivity after immersion in SBF. Atomic absorption spectroscopy (AAS) was used to determine the dissolution of calcium ions in the SBF media. Results showed that the prepared HA powder had a nanoscale structure with a size of 29 nm for the powder prepared by mechanical activation and 25 nm for the powder that was prepared by the sol gel method. The ionic dissolution rate of nano-structured powder was higher than conventional HA (with micro scale size) and was similar to biological apatite. It could be concluded that bioactivity behaviour of HA powder is affected by its crystallite size. Using the nano-structured HA powder with less than 50 nm crystallite size, the optimum bioactivity and bioresorbability would be achieved.

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Structural properties of hydroxyapatite obtained by mechanosynthesis

Cited by 123 publications

References 27 publications

Thermal Analysis on Hydroxyapatite Synthesis through Mechanochemical Method

Thermal Analysis on Hydroxyapatite Synthesis through Mechanochemical Method

Synthesis of Hydroxyapatite through Dry Mechanochemical Method and Its Conversion to Dense Bodies: Preliminary Result

Synthesis, characterization and bioactivity evaluation of nano-structured hydroxyapatite

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