Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation
Dara L. Dickstein,
Richard Zhang,
Ning Ru
et al.
Abstract:Evidence shows that ultra-high dose-rate FLASH-radiotherapy (FLASH-RT) protects against normal tissue complications and functional decrements in the irradiated brain. Past work has shown that radiation-induced cognitive impairment, neuroinflammation and reduced structural complexity of granule cell neurons were not observed to the same extent after FLASH-RT (> MGy/s) compared to conventional dose-rate (CONV, 0.1 Gy/s) delivery. To explore the sensitivity of different neuronal populations to cranial irradiat… Show more
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