Structural, physico-mechanical and in-vitro bioactivity studies on SiO2–CaO–P2O5–SrO–Al2O3 bioactive glasses

Tripathi, Himanshu; Rath, Chandana; Kumar, Ankush; Manna, Partha Pratim; Singh, Shailendra

doi:10.1016/j.msec.2018.09.041

Cited by 46 publications

(22 citation statements)

References 63 publications

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“…Their study demonstrated that Sr can participate effectively in the re-mineralization process of the bone [22]. Another study by Tripathi et al have shown that the released Sr ions from glass structure can show anti-cariogenic properties [23]. The main goal of this study is to investigate how Sr incorporation can affect the properties of the GICs.…”

Section: Influence Of Strontium On the Physical Mechanical And In-vimentioning

confidence: 95%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

J. Mod. Mater.

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In this work, we investigated the effects of strontium incorporation in the glass phase of glass ionomer cements (GIC). Three different glass compositions were synthesized with 0, 5, and 10 mol% of SrO addition. GICs were prepared by the addition of 50 wt% polyacrylic acid (PAA) at powder to liquid ratio of 1:1.5. Initial characterization on the cement series was to study their rheological behavior. Cements represented working times between 50-64 seconds and setting times of 356-452 seconds. Rheological results indicated that the addition of strontium decreases the working and setting times of the cements. To analyze the mechanical properties, compressive and flexural strength studies were performed after 1, 10, and 30 days incubation in simulated body fluid (SBF). The compressive strength of the cements increased as a function of incubation time, with the strontium containing compositions showing the highest strength at 34 megapascal (MPa) and after 30 days of incubation. Biaxial flexural strength of the cements was not significantly affected by the composition and maturation time and ranged between 13.4 to 16.3 MPa. In-vitro bioactivity of the cements was analyzed using SBF trials and after 1, 10, and 30 days incubation periods. Strontium containing cements, showed higher solubility with higher amounts of calcium phosphate surface depositions only after 10 days incubation. The elemental identifications of the surface depositions indicated high amounts of Ca, P and Zn are present on the surface of SBF incubated samples.

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Section: Influence Of Strontium On the Physical Mechanical And In-vimentioning

confidence: 95%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

J. Mod. Mater.

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“…The strontium addition in bioactive glasses combines the known regenerative properties of bioactive glasses with anabolic and anti‐catabolic effects of strontium ions. Alumina addition in contrast, in quantities above 3 mol% can inhibit or diminish the interaction between material and host, however, its addition in small (up to 2 mol%) quantities can enhance bioactivity, mechanical, and thermal properties …”

Section: Introductionmentioning

confidence: 99%

“…Alumina addition in contrast, in quantities above 3 mol% can inhibit or diminish the interaction between material and host, however, its addition in small (up to 2 mol%) quantities can enhance bioactivity, mechanical, and thermal properties. 16,17 Considering the modification of glass compositions, the careful design is the key factor to result in a suitable material for medical applications. The 45S5 Bioglass ® was calculated near an eutectic point in the ternary soda lime silicate diagram due to its low melting temperature and as a composition with a high content of alkali cations is prone to percolate into channels and to exhibit mixed alkali effect even with small changes in network connectivity.…”

Section: Introductionmentioning

confidence: 99%

Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium

et al. 2020

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The present research exposes the influence of 2 mol% of Al2O3 and 2 mol% SrO in 45S5 Bioglass®‐based compositions. Four compositions were produced to elucidate the difference in how both oxides influence structure and thermal behavior separately and their synergy when together. Thermal properties, crystallization tendency, and sintering behavior was evaluated by differential scanning calorimetry, hot stage microscopy, and dilatometry. Changes of medium‐range structures were characterized by Qn distribution of Raman spectroscopy and evaluation of 31P, 27Al, 23Na, and 29Si environment obtained by magic angle spinning nuclear magnetic resonance. Despite Qn distribution was predominantly Q2 in all samples, the composition criteria used enabled improved processing and stabilibity characteristics. The addition of Al2O3 and SrO promoted larger sinterability parameter (Sc) which indicates better sintering behavior, the glass stability against crystallization doubled (KH) compared to 45S5 and the processing window enlarged from 106 to 171.

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“…Following reports demonstrating the efficacy of the anti-osteoporosis drug strontium ranelate (SrRan) [ 9 , 10 ], strontium has been incorporated into BG for bone repair, as BG's amorphous nature allows it to deliver strontium at a sustained rate. In in vitro studies, strontium-substituted BGs increased the anabolic and anti-catabolic activity of osteoblasts and osteoclasts, respectively [ [11] , [12] , [13] ], and strontium-substituted materials showed enhanced bone formation and osteointegration in vivo [ [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”

Section: Introductionmentioning

confidence: 99%

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

et al. 2019

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The efficient healing of critical-sized bone defects using synthetic biomaterial-based strategies is promising but remains challenging as it requires the development of biomaterials that combine a 3D porous architecture and a robust biological activity. Bioactive glasses (BGs) are attractive candidates as they stimulate a biological response that favors osteogenesis and vascularization, but amorphous 3D porous BGs are difficult to produce because conventional compositions crystallize during processing. Here, we rationally designed a porous, strontium-releasing, bioactive glass-based scaffold (pSrBG) whose composition was tailored to deliver strontium and whose properties were optimized to retain an amorphous phase, induce tissue infiltration and encourage bone formation. The hypothesis was that it would allow the repair of a critical-sized defect in an ovine model with newly-formed bone exhibiting physiological matrix composition and structural architecture. Histological and histomorphometric analyses combined with indentation testing showed pSrBG encouraged near perfect bone-to-material contact and the formation of well-organized lamellar bone. Analysis of bone quality by a combination of Raman spectral imaging, small-angle X-ray scattering, X-ray fluorescence and focused ion beam-scanning electron microscopy demonstrated that the repaired tissue was akin to that of normal, healthy bone, and incorporated small amounts of strontium in the newly formed bone mineral. These data show the potential of pSrBG to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in large animal models.

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Structural, physico-mechanical and in-vitro bioactivity studies on SiO2–CaO–P2O5–SrO–Al2O3 bioactive glasses

Cited by 46 publications

References 63 publications

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

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Structural, physico-mechanical and in-vitro bioactivity studies on SiO2–CaO–P2O5–SrO–Al2O3 bioactive glasses

Cited by 46 publications

References 63 publications

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Structural and thermal behavior of 45S5 Bioglass®‐based compositions containing alumina and strontium

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

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Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium