Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution

Isaksson, Hanna; Töyräs, Juha; Hakulinen, Mikko; Aula, Antti; Tamminen, Inari S.; Julkunen, Petro; Kröger, Heikki; Jurvelin, Jukka S.

doi:10.1007/s00198-010-1219-0

Cited by 47 publications

(47 citation statements)

References 37 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variances among different studies are probably due to a combination of differences in skeletal sites, sample preparation, ultrasound measurement methodology, microCT hardware and microarchitectural feature estimation algorithm. A recent report addresses the effect of microCT image resolution (Isaksson et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…After ultrasound and DXA measurements had been performed, cancellous bone specimens were cut down to dimensions approximately 2.0 cm Â 4.0 cm Â 1.8 cm and imaged at an isotropic voxel size of 17.2 lm (nominal resolution). This resolution has been reported to be sufficient to reveal significant differences between normal and osteoporotic human trabecular bone for bone volume fraction (BV/TV), trabecular thickness (Tb.Th), degree of anisotropy (DA), trabecular number (Tb.N), trabecular spacing (Tb.Sp), and structural model index (SMI) (Isaksson et al, 2011). Within the 2.0 cm Â 4.0 cm Â 1.8 cm reconstruction volume, an interior volume, approximately 1.8 cm Â 3.6 cm Â 1.6 cm (similar to the DXA analysis volume) was delineated for micro-structural analysis.…”

Section: Microctmentioning

confidence: 99%

See 1 more Smart Citation

Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro

Wear

Nagaraja

Dreher

et al. 2012

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Ultrasound parameters (attenuation, phase velocity, and backscatter), bone mineral density (BMD), and microarchitectural features were measured on 29 human cancellous calcaneus samples in vitro. Regression analysis was performed to predict ultrasound parameters from BMD and microarchitectural features. The best univariate predictors of the ultrasound parameters were the indexes of bone quantity: BMD and bone volume fraction (BV/TV). The most predictive univariate models for attenuation, phase velocity, and backscatter coefficient yielded adjusted squared correlation coefficients of 0.69-0.73. Multiple regression models yielded adjusted correlation coefficients of 0.74-0.83. Therefore attenuation, phase velocity, and backscatter are primarily determined by bone quantity, but multiple regression models based on bone quantity plus microarchitectural features achieve slightly better predictive performance than models based on bone quantity alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Microctmentioning

confidence: 99%

Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro

Wear

Nagaraja

Dreher

et al. 2012

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

show abstract

“…A previous study demonstrated that it is the resolution of raw data that primarily determines the accuracy of models as the bone volume fraction of bone volume/total volume was predominantly affected by the scanning resolution (22). The scanning resolution of the µ-CT system used in our study was 33.355 µm, which was enough to depict the microarchitecture of human trabecular bone (23,24). In another study, the recommended resolution in finite element models of trabecular bone was one quarter of trabecular thickness (25).…”

Section: Discussionmentioning

confidence: 87%

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Wen

Yan

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Assessing the biomechanical properties of trabecular bone is of major biological and clinical significance for the research of bone diseases, fractures and their treatments. Micro-finite element (µFE) models are becoming increasingly popular for investigating the biomechanical properties of trabecular bone. The shapes of µFE models typically include cube and cylinder. Whether there are differences between cubic and cylindrical µFE models has not yet been studied. In the present study, cubic and cylindrical µFE models of human vertebral trabecular bone were constructed. A 1% strain was prescribed to the model along the superior-inferior direction. E values were calculated from these models, and paired t-tests were performed to determine whether these were any differences between E values obtained from cubic and cylindrical models. The results demonstrated that there were no statistically significant differences in the E values between cubic and cylindrical models, and there were no significant differences in Von Mises stress distributions between the two models. These findings indicated that, to construct µFE models of vertebral trabecular bone, cubic or cylindrical models were both feasible. Choosing between the cubic or cylindrical µFE model is dependent upon the specific study design.

show abstract

“…Macroscopic 3D bone geometry and inhomogeneities in bone mineral density (BMD) and mechanical properties can be assessed with quantitative CT (QCT) [50,51]. Unfortunately, the resolution of clinical CT equipment is insuffi cient to resolve trabecular architecture [52]. However, clinicallevel CT data can be used to measure the structural anisotropy for improved mechanical characterization of trabecular bone [53].…”

Section: Discussionmentioning

confidence: 99%

Importance of Material Properties and Porosity of Bone on Mechanical Response of Articular Cartilage in Human Knee Joint—A Two-Dimensional Finite Element Study

Venäläinen

Mononen

Jurvelin

et al. 2014

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

Mechanical behavior of bone is determined by the structure and intrinsic, local material properties of the tissue. However, previously presented knee joint models for evaluation of stresses and strains in joints generally consider bones as rigid bodies or linearly elastic solid materials. The aim of this study was to estimate how different structural and mechanical properties of bone affect the mechanical response of articular cartilage within a knee joint. Based on a cadaver knee joint, a two-dimensional (2D) finite element (FE) model of a knee joint including bone, cartilage, and meniscus geometries was constructed. Six different computational models with varying properties for cortical, trabecular, and subchondral bone were created, while the biphasic fibril-reinforced properties of cartilage and menisci were kept unaltered. The simplest model included rigid bones, while the most complex model included specific mechanical properties for different bone structures and anatomically accurate trabecular structure. Models with different porosities of trabecular bone were also constructed. All models were exposed to axial loading of 1.9 times body weight within 0.2 s (mimicking typical maximum knee joint forces during gait) while free varus-valgus rotation was allowed and all other rotations and translations were fixed. As compared to results obtained with the rigid bone model, stresses, strains, and pore pressures observed in cartilage decreased depending on the implemented properties of trabecular bone. Greatest changes in these parameters (up to -51% in maximum principal stresses) were observed when the lowest modulus for trabecular bone (measured at the structural level) was used. By increasing the trabecular bone porosity, stresses and strains were reduced substantially in the lateral tibial cartilage, while they remained relatively constant in the medial tibial plateau. The present results highlight the importance of long bones, in particular, their mechanical properties and porosity, in altering and redistributing forces transmitted through the knee joint.

show abstract

Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution

Abstract: The results suggest that structural differences between osteoporotic and normal trabecular bone may not be reliably detected with clinical CT scanners providing image voxel sizes above 100 µm.

Cited by 47 publications

References 37 publications

Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro

Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Importance of Material Properties and Porosity of Bone on Mechanical Response of Articular Cartilage in Human Knee Joint—A Two-Dimensional Finite Element Study

Contact Info

Product

Resources

About