Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP

Benedetto, Mélanie Di; Bièche, Ivan; Deshayes, Frédérique; Vacher, Sophie; Nouet, Sandrine; Collura, Vincent; Seitz, Isabell; Louis, Simon N.S.; Pineau, Pascal; Amsellem-Ouazana, Delphine; Couraud, Pierre‐Olivier; Strosberg, A. Donny; Stoppa‐Lyonnet, Dominique; Lidereau, Rosette; Nahmias, Clara

doi:10.1016/j.gene.2006.05.021

Cited by 89 publications

(109 citation statements)

References 34 publications

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“…In total, 62 of 830 (7.5%) probe sets found to be differentially expressed between T-PLL and ND-derived T-cell samples were located on chromosome 8 (Supplementary Table 2, Table 1). Interestingly, consistent with the loss of chromosomal material on 8p we found that the expression of the tumor suppressor gene MTUS1 35 was significantly downregulated as compared to normal controls. Also in accordance with the gain of chromosomal material, 40/ 41 differentially expressed genes located on 8q were found to be upregulated (Table 1).…”

Section: T-cell Prolymphocytic Leukemiasupporting

confidence: 82%

Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32)

et al. 2007

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Section: T-cell Prolymphocytic Leukemiasupporting

confidence: 82%

Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32)

et al. 2007

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“…Several splicing variants have been observed, each showing different tissue distribution. Comparison of amino acid sequences from different species revealed high conservation of this gene [35], suggesting that protein product of MTUS1 gene may play important roles in cellular homeostasis. Further study will be needed to fully characterize the molecular mechanisms utilized by MTUS1 as a functional tumor suppressor in HNSCC.…”

Section: Resultsmentioning

confidence: 99%

“…Recent structural analysis of the MTUS1 gene revealed that this gene comprises 17 coding exons [35]. The previous mutation analyses on this gene in liver cancer revealed that this gene is prone to various point mutations and small deletions which lead to the silencing of MTUS1 gene [23].…”

Section: Resultsmentioning

confidence: 99%

Genomic assessments of the frequent loss of heterozygosity region on 8p21.3∼p22 in head and neck squamous cell carcinoma

Pungpravat

Huang

et al. 2007

Cancer Genetics and Cytogenetics

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Most human cancers are characterized by genetic instabilities. Chromosomal aberrations include segments of allelic imbalance identifiable by loss of heterozygosity (LOH) at polymorphic loci, which may be used to implicate regions harboring tumor suppressor genes. Here we performed whole genome LOH profiling on over 40 human head and neck squamous cell carcinoma (HNSCC) cell lines. Several frequent LOH regions have been identified on chromosomal arms 3p, 4p, 4q, 5q, 8p, 9p, 10p, 11q, and 17p. A genomic region of ∼7 Mb located at 8p22-p21.3 exhibits the most frequent LOH (87.9%), which suggested that this region harbors important tumor suppressor gene(s). Mitochondrial tumor suppressor gene 1 (MTUS1) is a recently identified candidate tumor suppressor gene that resides in this region. Consistent down-regulation in expression was observed in HNSCC for MTUS1 as measured by real-time quantitative RT-PCR. Sequence analysis of MTUS1 gene in HNSCC revealed several important sequence variants in the exon regions of this gene. Thus, our results suggested that MTUS1 is one of the candidate tumor suppressor gene(s) reside in 8p22-p21.3 for HNSCC. The identification of these candidate genes will facilitate the understanding of tumorigenesis of HNSCC. Further studies are needed to functionally evaluate those candidate genes.

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“…MTUS1 has been identified as an 8p22 candidate tumor suppressor gene encoding a family of angiotensin II type 2 (AT2) receptor-interacting proteins (ATIPs). Alternative exon utilization of this gene leads to five known transcript variants that code for five different protein isoforms, namely ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4 (3,4). The ATIP polypeptides exhibit distinct motifs in the amino-terminus for localization to the cytosol, nucleus or cell membrane (ATIP1, ATIP3 and ATIP4, respectively), suggesting that MTUS1 gene products may be involved in a variety of intracellular functions in an AT2-dependent and -independent manner (3,4).…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway

Zhao

et al. 2015

Oncology Letters

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Abstract.Our previous studies demonstrated that the downregulation of microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor-interacting protein (MTUS1/ATIP) is associated with poor differentiation and prognosis in tongue squamous cell carcinoma (TSCC), and that ATIP1 exerts an antiproliferative effect on TSCC. The aim of the present study was to further investigate the anticancer effect of MTUS1/ATIP3a in TSCC. It was observed that UM1 cells (a TSCC cell line with high migration and invasion ability) exhibited lower expression of ATIP3a compared with UM2 cells (a TSCC cell line with lower migration and invasion ability). Restoration of ATIP3a expression in UM1 cells exerted antiproliferative effects and inhibited migration and invasion, whereas knockdown of ATIP3a promoted proliferation, migration and invasion in UM2 cells. Restoration of ATIP3a expression inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and the expression of Snai2 and vimentin in UM1 cells, whereas knockdown of ATIP3a promoted the phosphorylation of ERK1/2 and the expression of Snai2 and vimentin in UM2 cells. Therefore, MTUS1/ATIP3a was found to suppress the proliferation, migration and invasion of TSCC cells via the ERK1/2-Snai2 pathway.

show abstract

Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP

Cited by 89 publications

References 34 publications

Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32)

Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32)

Genomic assessments of the frequent loss of heterozygosity region on 8p21.3∼p22 in head and neck squamous cell carcinoma

Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway

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