Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent

Zhong, Bo; Vatolin, Sergei; Idippily, Nethrie D.; Lama, Rati; Alhadad, Laila Abdulmohsen; Reu, Frederic J.; Su, Bin

doi:10.1016/j.bmcl.2016.01.020

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…An assortment of therapeutics have been developed recently targeting epigenetic regulation, including DNA methyltransferase modulators, histone deacetylase modulators, histone acetyltransferase (HAT) modulators, and noncoding miRNAs, exhibiting possible effects against age-related disorders. , Among DNA methyltransferase modulators, 5-azacytidine (azacytidine, CAS RN 320-67-2) and 5-aza-2′-deoxycytidine (decitabine, CAS RN 2353-33-5) are the most thoroughly examined and demonstrate therapeutic potential against certain leukemias. , Histone deacetylase inhibitors include several chemical groups: cyclic peptides, hydroxamic acids, short chain fatty acids, and benzamides . Experimental evidence shows significant life-extending potential of the histone deacetylase inhibitors such as 4-phenylbutyrate (PBA), trichostatin A, sodium butyrate, and suberoylanilide hydroxamic acid (SAHA). , A wide range of histone deacetylase inhibitors are emerging as potential anticancer medications, including belinostat, panobinostat, SAHA and FK228, trichostatin A, sodium butyrate, vorinostat, valproic acid, and romidepsinor demonstrating considerable activity in hematological and solid tumors.…”

Section: Antiaging Drugsmentioning

confidence: 99%

“…339,340 Among DNA methyltransferase modulators, 5-azacytidine (azacytidine, CAS RN 320-67-2) and 5-aza-2′-deoxycytidine (decitabine, CAS RN 2353-33-5) are the most thoroughly examined and demonstrate therapeutic potential against certain leukemias. 341,342 Histone deacetylase inhibitors include several chemical groups: cyclic peptides, hydroxamic acids, short chain fatty acids, and benzamides. 343 Experimental evidence shows significant life-extending potential of the histone deacetylase inhibitors such as 4-phenylbutyrate (PBA), trichostatin A, sodium butyrate, and suberoylanilide hydroxamic acid (SAHA).…”

Section: Antiaging Drugsmentioning

confidence: 99%

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Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Tenchov,

Sasso,

Wang

et al. 2024

ACS Chem. Neurosci.

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Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-theart antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.

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Section: Antiaging Drugsmentioning

confidence: 99%

Section: Antiaging Drugsmentioning

confidence: 99%

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Tenchov,

Sasso,

Wang

et al. 2024

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

“…602,603 Among DNA methyltransferase modulators, 5-azacytidine (azacytidine, CAS # 320-67-2) and 5-aza-2′deoxycytidine (decitabine, CAS # 2353-33-5) are the most thoroughly examined and demonstrate therapeutic potential against certain leukemias. 604,605 Histone deacetylase inhibitors include several chemical groups: cyclic peptides, hydroxamic acids, short chain fatty acids, and benzamides. 606 Experimental evidence shows significant life-extending potential of the histone deacetylase inhibitors such as 4-phenylbutyrate (PBA), trichostatin A, sodium butyrate, and suberoylanilide hydroxamic acid (SAHA).…”

Section: Epigenetic Drugsmentioning

confidence: 99%

Aging Hallmarks and Anti-aging Strategies: A Landscape of Research Advancement

Tenchov

Sasso

Wang

et al. 2023

Preprint

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Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Thus, the major cellular and molecular hallmarks of aging have been identified and multiple strategies aiming to promoting healthy aging and extending the lifespan including lifestyle adjustments, medical treatments, and social programs, have been developed. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research. We review the advances in knowledge and delineate trends in research advancement on aging factors and attributes, as well as the anti-aging strategies across time, geography, and development pipelines. We also review the current concepts related to the major aging hallmarks on the molecular, cellular, and organismic level, the age-associated diseases, with attention to brain aging and brain health support, as well as the major biochemical processes associated with aging. We further assess the state-of-the-art anti-aging strategies and explore their correlations with age-related diseases. Well-recognized and novel, currently evaluated anti-aging agents have been summarized. Finally, we review clinical applications of anti-aging products with their development pipelines. We hope this review will be helpful for apprehending the current knowledge in the field of aging progression and prevention, in effort to further solve the remaining challenges and fulfil its potential.

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“…305 Another strategy consisted in synthesizing the 3-substituted hydantoin via the cyclization of an ureido intermediate and then to perform Knoevenagel condensation to afford the desired hydantoins. The intermediate was prepared from an isocyanate, 306 commercially available 307 or generated from the corresponding amine with triphosgene 308 or oxalyl chloride. 309 Interestingly, when Hidayat et al performed the condensation reaction of 3-substituted hydantoins and different benzaldehydes under microwave irradiation, the major products obtained were not the expected benzylhydantoins but the corresponding benzylhydantoin alcohols, underlining the fact that microwave conditions favored the formation of the C−C bond but did not accelerated the dehydration step of the reaction.…”

Section: -Substituted 5-alkyl/arylidene Hydantoinsmentioning

confidence: 99%

“…Another strategy consisted in synthesizing the 3-substituted hydantoin via the cyclization of an ureido intermediate and then to perform Knoevenagel condensation to afford the desired hydantoins. The intermediate was prepared from an isocyanate, commercially available or generated from the corresponding amine with triphosgene or oxalyl chloride…”

Section: Alkylidene Hydantoinsmentioning

confidence: 99%

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

et al. 2017

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The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

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Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent

Cited by 7 publications

References 6 publications

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Aging Hallmarks and Anti-aging Strategies: A Landscape of Research Advancement

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

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