Structural network changes in patients with major depression and schizophrenia treated with electroconvulsive therapy

Nolte, Henrike Maria; Hirjak, Dušan; Hofer, Stefan; Seidl, Ulrich; Depping, Malte S.; Stieltjes, Bram; Maier‐Hein, Klaus H.; Sambataro, Fabio; Thomann, Philipp A.

doi:10.1016/j.euroneuro.2016.06.008

Cited by 38 publications

(35 citation statements)

References 52 publications

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“…A total of 18 studies met the inclusion criteria for our systematic-review (online Table DS1). 12,18,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] A total of 193 participants from eight independent studies were selected for the meta-analysis. Of these, five independent studies (n = 100) reported volume changes in amygdala.…”

Section: Resultsmentioning

confidence: 99%

Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

et al. 2018

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“…SBM decomposition of subjects-by-voxel data matrix results in spatial maps, which are the sources of covariance, and a mixing matrix that indicates the contribution for each subject for each source. We have previously applied SBM to structural data to investigate neural effects associated with electroconvulsive therapy in MDD (Wolf et al ., 2016), as well as effects of psychotherapy in patients with substance-use disorders (Fahmy et al ., 2019), where SBM has been shown to be sensitive to treatment related changes of neural network strength. This technique has also been used previously on functional imaging data, including SPECT (Premi et al ., 2017).…”

Section: Methodsmentioning

confidence: 99%

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

et al. 2019

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BackgroundCognitive impairment is a core feature of major depressive disorder (MDD). Cognitive remediation may improve cognition in MDD, yet so far, the underlying neural mechanisms are unclear. This study investigated changes in intrinsic neural activity in MDD after a cognitive remediation trial.MethodsIn a longitudinal design, 20 patients with MDD and pronounced cognitive deficits and 18 healthy controls (HC) were examined using resting-state functional magnetic resonance imaging. MDD patients received structured cognitive remediation therapy (CRT) over 5 weeks. The whole-brain fractional amplitude of low-frequency fluctuations was computed before the first and after the last training session. Univariate methods were used to address regionally-specific effects, and a multivariate data analysis strategy was employed to investigate functional network strength (FNS).ResultsMDD patients significantly improved in cognitive function after CRT. Baseline comparisons revealed increased right caudate activity and reduced activity in the left frontal cortex, parietal lobule, insula, and precuneus in MDD compared to HC. In patients, reduced FNS was found in a bilateral prefrontal system at baseline (p < 0.05, uncorrected). In MDD, intrinsic neural activity increased in right inferior frontal gyrus after CRT (p < 0.05, small volume corrected). Left inferior parietal lobule, left insula, left precuneus, and right caudate activity showed associations with cognitive improvement (p < 0.05, uncorrected). Prefrontal network strength increased in patients after CRT, but this increase was not associated with improved cognitive performance.ConclusionsOur findings support the role of intrinsic neural activity of the prefrontal cortex as a possible mediator of cognitive improvement following CRT in MDD.

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“…It was also demonstrated that administration of ECT leads to significant increase in the network strength of the ACC/MPFC network and the MTL network though the increase in network strength and symptom amelioration were not correlated. [ 32 ]…”

Section: Structural and Functional Neuroimaging Studiesmentioning

confidence: 99%

Does electroconvulsive therapy cause brain damage: An update

Jolly

Singh

2020

Indian J Psychiatry

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Electroconvulsive therapy (ECT) is an effective modality of treatment for a variety of psychiatric disorders. However, it has always been accused of being a coercive, unethical, and dangerous modality of treatment. The dangerousness of ECT has been mainly attributed to its claimed ability to cause brain damage. This narrative review aims to provide an update of the evidence with regard to whether the practice of ECT is associated with damage to the brain. An accepted definition of brain damage remains elusive. There are also ethical and technical problems in designing studies that look at this question specifically. Thus, even though there are newer technological tools and innovations, any review attempting to answer this question would have to take recourse to indirect methods. These include structural, functional, and metabolic neuroimaging; body fluid biochemical marker studies; and follow-up studies of cognitive impairment and incidence of dementia in people who have received ECT among others. The review of literature and present evidence suggests that ECT has a demonstrable impact on the structure and function of the brain. However, there is a lack of evidence at present to suggest that ECT causes brain damage.

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Structural network changes in patients with major depression and schizophrenia treated with electroconvulsive therapy

Cited by 38 publications

References 52 publications

Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

Does electroconvulsive therapy cause brain damage: An update

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