Structural Modifications of Drug Candidates: How Useful Are They in ImprovingPKParameters of New Drugs? PartII: Drug Design Strategies

Abstract

The prodrug approach has been widely used in drug design. Prodrugs most commonly use either oxidative or reductive activation. Considering the risks and costs of new drug development, it is critical to eliminate high‐risk compounds as early as possible. The article discusses various factors related to structural modification and drug design strategies.