Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe

Zhang, Chuangli; An, Jusung; Wu, Jiasheng; Liu, Weimin; Rha, Hyeonji; Kim, Jong Seung; Wang, Pengfei

doi:10.1016/j.bios.2022.114701

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…[2] FLI allows to monitor the internal structure and physiological processes of organisms and cells in real time, without interfering with normal physiological activities. Thus, FLI has shown potential in cancer imaging, [3] angiography, [4] disease diagnosis, [5] and image-guided surgical treatment, etc. [6] However, visible light (400-700 nm) and the first near-infrared (NIR-I, 700-900 nm) fluorescence resulted in limited propagation distance due to the absorption of water, hemoglobin, and oxyhemoglobin, which are abundant in biological tissues.…”

Section: Introductionmentioning

confidence: 99%

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Hu,

Feng,

Yang

2024

Adv Funct Materials

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Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority in deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration due to their low biotoxicity, high biocompatibility, rapid clearance, and good modification properties. As the key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role in the construction of donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes the research development of NIR‐II small molecule fluorophores based on BTD derivatives in the field of bioimaging, focusing on molecular design and photophysical properties, and introduces a part of the applications in the biological field. Furthermore, the challenges of BTD‐based NIR‐II fluorophores in the future development and application are discussed .

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Section: Introductionmentioning

confidence: 99%

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Hu,

Feng,

Yang

2024

Adv Funct Materials

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“…Phototheranostics, including high-sensitivity fluorescence imaging (FLI), [1][2][3][4][5][6] photodynamic therapy (PDT), [7][8][9][10][11][12][13] and photothermal therapy (PTT), [14][15][16][17][18][19] is an approach for diagnosing and treating various diseases, especially cancers, due to its noninvasiveness, real-time feedback, and harmlessness to healthy tissues. [20][21][22][23][24] Upon laser irradiation, photosensitizers could generate cytotoxic reactive oxygen species (ROS) or/and thermal effects, which play a crucial role in eliminating cancer cells.…”

Section: Introductionmentioning

confidence: 99%

A selenium-based NIR-II photosensitizer for a highly effective and safe phototherapy plan

Zhang,

Li,

Guan

et al. 2024

Analyst

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Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging

Zeng,

Li,

Wang

et al. 2024

Advanced Science

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Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and blurry tumor boundaries. Besides, intraoperative frozen‐section analysis of resection margins of OS is often restricted by the hard tissues around OS, which makes it impossible to know whether a negative margin is achieved. Any unresected small tumor residuals will lead to local recurrence and worse prognosis. Herein, based on the high expression of B7H3 in OS, a targeted probe B7H3‐IRDye800CW is synthesized by conjugating anti‐B7H3 antibody and IRDye800CW. B7H3‐IRDye800CW can accurately label OS areas after intravenous administration, thereby helping surgeons identify and resect residual OS lesions (<2 mm) and lung metastatic lesions. The tumor‐background ratio reaches 4.42 ± 1.77 at day 3. After incubating fresh human OS specimen with B7H3‐IRDye800CW, it can specifically label the OS area and even the microinvasion area (confirmed by hematoxylin‐eosin [HE] staining). The probe labeled area is consistent with the tumor area shown by magnetic resonance imaging and complete HE staining of the specimen. In summary, B7H3‐IRDye800CW has translational potential in intraoperative resection guidance and rapid pathological diagnosis of OS.

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Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe

Cited by 5 publications

References 40 publications

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

A selenium-based NIR-II photosensitizer for a highly effective and safe phototherapy plan

Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging

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