We have prepared organic-inorganic hybrid materials (OIHM), incorporating an organic phase in the inorganic precursor sol in combination with the assisted high power ultrasounds. A sonoormosil, results after gelation. Colloidal silica particles have been added to these hybrids to enable network porous volume and pore radius to be tailored. Finally, in vitro bioactivity of this material has been promoted by adding calcium to the initial sol. The structure and bioactivity of these materials have been studied as preliminary step that includes their mechanical behaviour. These materials have a very fine structure especially when colloidal silica particles are included. When are immersed in a solution simulating blood plasma they are bioactive, presenting a better in vitro behaviour the sample with colloid particles