Structural measurements and cell line studies of the copper–PEG–Rifampicin complex against Mycobacterium tuberculosis

Manning, Thomas J.; Mikula, Rachel; Wylie, Greg; Phillips, Dennis; Jarvis, Jackie; Zhang, Fengli

doi:10.1016/j.bmcl.2014.12.053

Cited by 10 publications

(2 citation statements)

References 24 publications

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“…6b). Our choice of Cu was based on evidence of its anti-TB potential (Festa R.A. et al, 2014;Neyrolles O. et al, 2015;Speer A. et al, 2013;Wolschendorf F. et al, 2011) as well as demonstrated in vitro synergy with other known anti-TB drugs (Manning T. et al, 2015a;Speer A. et al, 2013). POA has been explored as an anti-TB candidate since it is considered a prodrug of pyrazinamide (PZA), a current first line TB drug experiencing drug resistance from Mtb (Durham P.G.…”

Section: Aerosolized Mofs For Pulmonary Therapymentioning

confidence: 99%

Consideration of Metal Organic Frameworks for Respiratory Delivery

Stewart

Luz

Mortensen

2021

KONA

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Metal organic frameworks (MOFs) have garnered increased attention over the past 20 years. Due to their porosity, high surface area, and nearly limitless customization and tunability MOFs have been designed for applications ranging from gas storage and separation to catalysis to sensing to biomedical engineering. Within the latter category, MOFs offer an appealing function for drug delivery as they can be loaded with multiple therapeutic moieties tailored to target specific disorders with triggered and controlled release characteristics. However, there is an unmet need to assess their viability for pulmonary treatment via inhalation. Targeting pulmonary disorders including infectious diseases by delivering medication directly to the lungs attacks the primary site of infection rather than relying on systemic distribution. The inherent advantage of this strategy is maximizing local lung concentrations of the drug. An introduction to inhaled therapies is provided here as a preamble to a brief summary of the current development state of MOF drug delivery systems. This review is intended to highlight the relative disparity between research toward MOFs as pulmonary drug delivery vehicles compared to other delivery platforms. Prospective biomedical applications for inhalable MOFs are also discussed.

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Section: Aerosolized Mofs For Pulmonary Therapymentioning

confidence: 99%

Consideration of Metal Organic Frameworks for Respiratory Delivery

Stewart

Luz

Mortensen

2021

KONA

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“…For example, the polyethylene glycol (PEG-PLGA/magnetite (γ-Fe 2 O 3 )) co-assembled with the antibiotic cotrimoxazole resulted in an excellent delivery system for the release of a drug via an external magnetic impulse [159]. Similarly, Au-conjugated PLGA-PEG-succinate-PEG-PLGA NPs assembled with Rf exhibited a time-controlled release useful for a long-term personalized therapy [160] and, similarly, Rf-Cu complexes were assembled in several structures with PEGs of different length [161].…”

Section: Delivery Systems For Antibacterial Compounds In Tbmentioning

confidence: 99%

Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

Natale

Benedictis

et al. 2020

Antibiotics

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In metal-peptide interactions, cations form stable complexes through bonds with coordinating groups as side chains of amino acids. These compounds, among other things, exert a wide variety of antimicrobial activities through structural changes of peptides upon metal binding and redox chemistry. They exhibit different mechanisms of action (MOA), including the modification of DNA/RNA, protein and cell wall synthesis, permeabilization and modulation of gradients of cellular membranes. Nowadays, the large increase in antibiotic resistance represents a crucial problem to limit progression at the pandemic level of the diseases that seemed nearly eradicated, such as tuberculosis (Tb). Mycobacterium tuberculosis (Mtb) is intrinsically resistant to many antibiotics due to chromosomal mutations which can lead to the onset of novel strains. Consequently, the maximum pharmaceutical effort should be focused on the development of new therapeutic agents and antimicrobial peptides can represent a valuable option as a copious source of potential bioactive compounds. The introduction of a metal center can improve chemical diversity and hence specificity and bioavailability while, in turn, the coordination to peptides of metal complexes can protect them and enhance their poor water solubility and air stability: the optimization of these parameters is strictly required for drug prioritization and to obtain potent inhibitors of Mtb infections with novel MOAs. Here, we present a panoramic review of the most recent findings in the field of metal complex-peptide conjugates and their delivery systems with the potential pharmaceutical application as novel antibiotics in Mtb infections.

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Generation of a personal chemical profile from skeletonized human remains

Edson¹

2023

Forensic Genetic Approaches for Identification of Human Skeletal Remains

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Structural measurements and cell line studies of the copper–PEG–Rifampicin complex against Mycobacterium tuberculosis

Cited by 10 publications

References 24 publications

Consideration of Metal Organic Frameworks for Respiratory Delivery

Consideration of Metal Organic Frameworks for Respiratory Delivery

Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

Generation of a personal chemical profile from skeletonized human remains

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