Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease
Zhongyue Guo,
Giulio Chiesa,
Jiaze Yin
et al.
Abstract:While protein aggregation is a hallmark of many neurodegenerative diseases, acquiring structural information on protein aggregates inside live cells remains challenging. Traditional microscopy does not provide structural information on protein systems. Routinely used fluorescent protein tags, such as Green Fluorescent Protein (GFP), might perturb native structures. Here, we report a counter‐propagating mid‐infrared photothermal imaging approach enabling mapping of secondary structure of protein aggregates in l… Show more
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