Structural magnetic imaging of the hippocampus in early onset schizophrenia

Matsumoto, Hideo; Simmons, Andrew; Williams, Steven; Pipe, Roderic; Murray, Robin M.; Frangou, Sophia

doi:10.1016/s0006-3223(01)01073-3

Cited by 60 publications

(29 citation statements)

References 37 publications

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“…47 It is unclear whether reductions in the hippocampus and caudate nucleus in antipsychotic-naive schizophrenia are associated with psychopathology and illness duration. Although not significant, our observation of a weak association between longer duration of untreated illness and reduced hippocampal volume is in line with those of Matsumoto and colleagues, 11 suggesting that hippocampal changes may occur during the transition to psychosis. 48 Associations between structural abnormalities and clinical variables presumably reflect underlying pathophysiologic disturbances in neurotransmission, metabolism and genetic variance, and different mechanisms may underlie positive and negative symptoms.…”

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confidence: 92%

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Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia

Ebdrup

Glenthøj

Rasmussen

et al. 2010

jpn

111

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95Background: Enlarged ventricles and reduced hippocampal volume are consistently found in patients with first-episode schizophrenia. Studies investigating brain structure in antipsychotic-naive patients have generally focused on the striatum. In this study, we examined whether ventricular enlargement and hippocampal and caudate volume reductions are morphological traits of antipsychotic-naive firstepisode schizophrenia. Methods: We obtained high-resolution 3-dimensional T 1 -weighted magnetic resonance imaging scans for 38 antipsychotic-naive first-episode schizophrenia patients and 43 matched healthy controls by use of a 3-T scanner. We warped the brain images to each other by use of a high-dimensional intersubject registration algorithm. We performed voxel-wise group comparisons with permutation tests. We performed small volume correction for the hippocampus, caudate and ventricles by use of a false discovery rate correction (p < 0.05) to control for multiple comparisons. We derived and analyzed estimates of brain structure volumes. We grouped patients as those with (n = 9) or without (n = 29) any lifetime substance abuse to examine the possible effects of substance abuse. Results: We found that hippocampal and caudate volumes were decreased in patients with first-episode schizophrenia. We found no ventricular enlargement, differences in global volume or significant associations between tissue volume and duration of untreated illness or psychopathology. The hippocampal volume reductions appeared to be influenced by a history of substance abuse. Exploratory analyses indicated reduced volume of the nucleus accumbens in patients with first-episode schizophrenia. Limitations: This study was not a priori designed to test for differences between schizophrenia patients with or without lifetime substance abuse, and this subgroup was small. Conclusion: Reductions in hippocampal and caudate volume may constitute morphological traits in antipsychotic-naive first-episode schizophrenia patients. However, the clinical implications of these findings are unclear. Moreover, past substance abuse may accentuate hippocampal volume reduction. Magnetic resonance imaging studies addressing the potential effects of substance abuse in antipsychoticnaive first-episode schizophrenia patients are warranted.

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confidence: 92%

“…However, hippocampal reductions may be associated with illness duration and psycho pathology. 11 Ventricular enlargement is also not specific for schizophrenia. 12 Nevertheless, recent studies suggest that ventricular enlargement may progress during the course of the disease and may be related to outcome 13 or antipsychotic treatment.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia

Ebdrup

Glenthøj

Rasmussen

et al. 2010

jpn

111

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“…Velakoulis Several studies have also assessed hippocampal volumes in childhood-onset schizophrenia. However, whereas some studies have shown reduction of the left hippocampus after a 2-year follow-up in comparison to controls, 292 or bilateral hippocampal volume loss over time, 293 others did not find smaller hippocampi in early-onset schizophrenia, 294,295 although it seems that normal hippocampal asymmetry (right greater than left) is lacking in childhood-onset schizophrenia. 294,296 Barta et al 297 examined hippocampal volumes in patients with late-onset schizophrenia, AD, and normal elderly controls.…”

Section: Schizophreniamentioning

confidence: 90%

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

2004

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Magnetic resonance imaging (MRI) has opened a new window to the brain. Measuring hippocampal volume with MRI has provided important information about several neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. Smaller hippocampal volumes have been reported in epilepsy, Alzheimer's disease, dementia, mild cognitive impairment, the aged, traumatic brain injury, cardiac arrest, Parkinson's disease, Huntington's disease, Cushing's disease, herpes simplex encephalitis, Turner's syndrome, Down's syndrome, survivors of low birth weight, schizophrenia, major depression, posttraumatic stress disorder, chronic alcoholism, borderline personality disorder, obsessive-compulsive disorder, and antisocial personality disorder. Significantly larger hippocampal volumes have been correlated with autism and children with fragile X syndrome. Preservation of hippocampal volume has been reported in congenital hyperplasia, children with fetal alcohol syndrome, anorexia nervosa, attention-deficit and hyperactivity disorder, bipolar disorder, and panic disorder. Possible mechanisms of hippocampal volume loss in neuropsychiatric disorders are discussed.

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“…The Neuroscientist 18 (2) Study or Subgroup Altshuler et al, 1998Baiano et al, 2008Becker et al, 1990Breier et al, 1992Chakos et al, 2005Chakos et al, 2005c Ebdrup et al, 2010Exner et al, 2008Frazier et al, 2008Fukuzako et al, 1996Fukuzako et al, 1997Gur et al, 2000Kuroki et al, 2006Levitt et al, 2001Marsh et al, 1997Matsumoto et al, 2001Meisenzahl et al, 2009Meisenzahl et al, 2009c Niemann et al, 2000Rajarethinam et al, 2001Rametti et al, 2007Razi et al, 1999Razi et al, 1999c Rupp et al, 2005Rusch et al, 2008Sachdev et al, 2000Sallet et al, 2003Sanfilipo et al, 2000Sim et al, 2006Smith et al, 2003Spoletini et al, 2011c Strasser et al, 2005Sumich et al, 2002 Suzuki et al, 2005 (b) Swayze et al, 1992Szendi et al, 2006Szeszko et al, 2003Takahashi et al, 2006Tanskanen et al, 2005Velakoulis et al, 1999Velakoulis et al, 1999c Verma et al, 2009Weiss et al, 2005…”

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confidence: 99%

Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia

2011

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Several magnetic resonance imaging studies have reported hippocampal volume reduction in patients with schizophrenia, but other studies have reported contrasting results. In this review and meta-analysis, the authors aim to clarify whether a reduction in hippocampal volume characterizes patients with schizophrenia by considering illness phase (chronic and first episode) and hippocampus side separately. They made a detailed literature search for studies reporting physical volumetric hippocampal measures of patients with schizophrenia and healthy control (HC) participants and found 44 studies that were eligible for meta-analysis. Individual meta-analyses were also performed on 13 studies of first-episode patients and on 22 studies of chronic patients. The authors also detected any different findings when only males or both males and females were considered. Finally, additional meta-analyses and analyses of variance investigated the role of the factors "illness phase" and "side" on hippocampal volume reduction. Overall, the patient group showed significant bilateral hippocampal volume reduction compared with HC. Interestingly, first-episode and chronic patients showed same-size hippocampal volume reduction. Moreover, the left hippocampus was smaller than the right hippocampus in patients and HC. This review and meta-analysis raises the question about whether hippocampal volume reduction in schizophrenia is of neurodevelopmental origin. Future studies should specifically investigate this issue.

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Structural magnetic imaging of the hippocampus in early onset schizophrenia

Cited by 60 publications

References 37 publications

Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia

Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia

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