Structural investigation of the antibiotic ristomycin A: The 13C-NMR evidence on the carbohydrate moieties and their linkages to the aglycone

The Vancomycin Group of Antibiotics and the Fight against Resistant Bacteria

“…In the structure determination of ristocetin A (2), important work on the sugars was carried out in Hungary, [16] but the structure of the peptide portion was determined in our own group. [17] This was followed by the structure determination of teicoplanin (3), which was carried out in our group and completed in 1984.…”

“…The increasing power of proton NMR spectroscopy meant that other structural determinations of members of the vancomycin group could be carried out relatively quickly compared to the pioneering work on vancomycin. In the structure determination of ristocetin A (2), important work on the sugars was carried out in Hungary, [16] but the structure of the peptide portion was determined in our own group. [17] This was followed by the structure determination of teicoplanin (3), which was carried out in our group and completed in 1984.…”

Liquid chromatographic enantioseparation, determination, bioassay and isolation of enantiomers of Ketorolac: A review

“…The lower limit of detection was 0.01 mg mL À1 . a 1 -Acid glycoprotein Chiral-AGP columns (first developed by immobilization of orosomucoid onto silica microparticles by Hermansson in 1983) [22], were relatively more extensively used in comparison to the CSPs containing human serum albumin, or (S)-tert-leucine, or Ristocetin A, a glycopeptide antibiotic [23] as the chiral selectors, during the same period. a 1 -Acid glycoprotein (AGP) or ovomucoid based CSPs are expensive to the extent that they are out of reach of majority of small laboratories and Institutes and have a short life with limited applications and do suffer with one or more types of limitations as they require (a) storage in a solution of isopropanol-water (2:8, v/v) at room temperature or at 1-4 8C when not in use, and (b) washing after each use with water for 30 min followed by washing with isopropanol-water (2:8, v/v) for 30 min; mobile phase with greater than 25% isopropanol is not recommended as it may cause protein precipitation.…”

Die Vancomycin-Antibiotica und der Kampf gegen resistente Bakterien

“…Beim Ristocetin A 2 wurden wichtige Arbeiten über die Zuckerreste in Ungarn durchgeführt, [16] während die Struktur des Peptidteils in unserer eigenen Gruppe aufgeklärt wurde. [17] Danach konnten wir bis 1984 die Struktur von Teicoplanin 3 vollständig bestimmen.…”