Structural investigation of polysaccharides and nanocompositions based on them

Fazilova, S. A.; Yugai, S. M.; Рашидова, С. Ш.

doi:10.1134/s1068162011070053

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Разработана биологически активная добавка добавка -арабиногалактан (АГ), выделенный из лиственницы. Новизна и оригинальность препарата подтверждены выдачей патента [7].…”

Section: результаты и обсуждениеunclassified

“…Показано [3][4][5][6], что АГ из западной лиственницы может служить целенаправленным носителем для доставки диагностических и терапевтических агентов, а также ферментов, нуклеиновых кислот, витаминов или гормонов, к определенным клеткам, в частности, гепатоцитам -паренхимным клеткам печени. В модельных экспериментах АГ из лиственницы показал высокую мембранотропность [7]. Благодаря этому его можно использовать для повышения всасываемости других биологически активных ингредиентов, характеризующихся низкой биодоступностью [2,5,7].…”

Section: результаты и обсуждениеunclassified

“…В модельных экспериментах АГ из лиственницы показал высокую мембранотропность [7]. Благодаря этому его можно использовать для повышения всасываемости других биологически активных ингредиентов, характеризующихся низкой биодоступностью [2,5,7]. При этом образуется комплекс между доставляемым агентом и арабиногалактаном, способным взаимодействовать с асиалогликопротеиновым рецептором клетки.…”

Section: результаты и обсуждениеunclassified

“…Механохимическую обработку исходных компонентов проводили в ротационной (валковой) мельницей ВМ-1 с барабаном, имеющим фторопластовую футеровку. Полученный мелкодисперсный порошок растворяли в воде, нейтрализацию смеси проводили водным щелочным раствором и сушили методом распылительной или вакуумной сушки [7].…”

Section: результаты и обсуждениеunclassified

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Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix

Shelepov,

Byambaa,

Chelnakova

et al. 2023

Vestn. Voronež. gos. univ. inž. tehnol.

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The possibility of combining complexly soluble arabinogalactan polysaccharides with chitosan polysaccharides to increase the absorption of biologically active substances and compounds characterized by low bioavailability is being considered. Included in the biologically active biopolymer matrix are chitosan succinate, succinic anhydrite, arabinogalactan and dihydroquercetin, respectively, in quantities, wt. %: 3–5.0; 2.0–4.0; 15.0–20.0 and 3.5 can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, including enzymes, nucleic acids, vitamins, hormones, etc. to certain cells, in particular, hepatocytes (liver parenchyma cells). The high membranotropic properties of arabinogalactan isolated from larch have been established, which allows its use to increase the absorption in the gastrointestinal tract of other functionally active ingredients with low bioavailability. The mechanism of this action is associated with the formation of a binding complex between arabinogalactan and the delivered agent, which has the ability to interact with the asialoglycoprotein cell receptor. Studies have been carried out on the possibility of combining arabinogalactan polysaccharides with chitosan polysaccharides to obtain a biopolymer matrix, which includes chitosan succinate, succinic anhydride and arabinogalactan containing dihydroquercetin not covalently bound to it. Along with the above properties, the effectiveness of using arabinogalactan is shown using the example of its use to improve the technological and functional characteristics of broiler chicken meat with PSE traits. The addition of arabinogalactan to the recipe composition of minced meat during the production of sausages, in an amount of 0.5% of the main raw material, increased the moisture-binding capacity by 5% while reducing losses during heat treatment by 6%. There was an improvement in peroxide and acid numbers during storage, which ensures inhibition of oxidative processes and prevents spoilage of finished products.

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Section: результаты и обсуждениеunclassified

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Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix

Shelepov,

Byambaa,

Chelnakova

et al. 2023

Vestn. Voronež. gos. univ. inž. tehnol.

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“…A certain role in the manifestation of biological activity belongs to the localization of the polysaccharide in the plant cell [1]. It was shown [3][4][5][6] that hypertension from western larch can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, as well as enzymes, nucleic acids, vitamins or hormones, to certain cells, in particular hepatocytes (parenchymal cells liver. In model experiments, hypertension from larch showed high membranotropy [7].…”

Section: Opinionmentioning

confidence: 99%

Innovative Prospects for The Creation of Medical Products Based on The Polysaccharide Matrix

VG¹

2020

BJSTR

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The presented material considers the possibility of combining sparingly soluble polysaccharides with plant polysaccharides to increase the absorption of drugs with low bioavailability, as biologically active substances they can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, as well as enzymes, nucleic acids, vitamins or hormones, to certain cells, in particular hepatocytes (parenchymal liver cells). A method for preparing a composition of arabinogalactan and chitosan succinate is described, examples of its practical use in medicine, veterinary medicine and animal husbandry are given.

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Nanocrystalline Cellulose: Green, Multifunctional and Sustainable Nanomaterials

Julkapli

Mansouri

2017

Handbook of Composites From Renewable Materials

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Structural investigation of polysaccharides and nanocompositions based on them

Cited by 5 publications

References 28 publications

Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix

Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix

Innovative Prospects for The Creation of Medical Products Based on The Polysaccharide Matrix

Nanocrystalline Cellulose: Green, Multifunctional and Sustainable Nanomaterials

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