Structural Insights into the Mechanism of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly

Herrmann, Dominik; Zhou, Lynne W.; Hanson, Heather; Willkomm, Nora A.; Mansky, Louis M.; Saad, Jamil S.

doi:10.1016/j.jmb.2021.167161

Cited by 5 publications

(1 citation statement)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MA domain of Gag is responsible for the membrane-binding activity of the protein, which anchors the protein within lipid rafts at the plasma membrane (83)(84)(85)(86)(87). For both HIV-1 and HTLV-1, electrostatic interactions between the highly basic region of MA and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ] are key regulators of membrane binding, though recent research suggests that co-translational myristoylation of the G2 position in MA is the primary driver of HTLV-1 Gag membrane binding (88,89).…”

Section: Assembly Budding and Maturationmentioning

confidence: 99%

Molecular Biology and Diversification of Human Retroviruses

Meissner

Talledge²,

Mansky³

2022

Front.Virol.

Self Cite

View full text Add to dashboard Cite

Studies of retroviruses have led to many extraordinary discoveries that have advanced our understanding of not only human diseases, but also molecular biology as a whole. The most recognizable human retrovirus, human immunodeficiency virus type 1 (HIV-1), is the causative agent of the global AIDS epidemic and has been extensively studied. Other human retroviruses, such as human immunodeficiency virus type 2 (HIV-2) and human T-cell leukemia virus type 1 (HTLV-1), have received less attention, and many of the assumptions about the replication and biology of these viruses are based on knowledge of HIV-1. Existing comparative studies on human retroviruses, however, have revealed that key differences between these viruses exist that affect evolution, diversification, and potentially pathogenicity. In this review, we examine current insights on disparities in the replication of pathogenic human retroviruses, with a particular focus on the determinants of structural and genetic diversity amongst HIVs and HTLV.

show abstract