Abstract:The 826 human G protein‐coupled receptors (GPCRs) are involved in nearly every physiological process and comprise the largest class of “druggable” proteins. For over the past decade, crystal and cryo‐EM structures have focused on revealing molecular details of GPCR interactions with small molecules and intracellular partner proteins, which are well‐established regulators of GPCR function. More recently, literature data from biological and biophysical studies have demonstrated that phospholipids found in the en… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.