Structural idiosyncrasies of glycyl T-box riboswitches among pathogenic bacteria
Nikoleta Giarimoglou,
Adamantia Kouvela,
Jinwei Zhang
et al.
Abstract:T-box riboswitches are widespread bacterial regulatory noncoding RNAs that directly interact with tRNAs and switch conformations to regulate the transcription or translation of genes related to amino acid metabolism. Recent studies in Bacilli have revealed the core mechanisms of T-boxes that enable multivalent, specific recognition of both the identity and aminoacylation status of the tRNA substrates. However, in-depth knowledge of a vast number of T-boxes in other bacterial species remains scarce, although a … Show more
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