“…The wealth of structural data available on BoNT/A subtype cell-binding domains (H C /A1 to H C /A6) alone and in complex with their receptors have revealed features related to SV2 and ganglioside receptor binding [ 37 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. In particular, the structure of H C /A1 in complex with human glycosylated SV2C [ 37 ] and of H C /A1 to H C /A6 in complex with the ganglioside GD1a (GM1b for H C /A5) [ 85 , 86 , 87 , 88 , 89 , 90 ] ( Table 1 ) have identified six structural features that appear to be common to the cell-binding domain ( Figure 4 ).…”