Structural features and immunostimulating effects of three acidic polysaccharides isolated from Panax quinquefolius

Wang, Lijun; Yao, Yang; Sang, Wei; Yang, Xiushi

doi:10.1016/j.ijbiomac.2015.06.007

Cited by 40 publications

(31 citation statements)

References 34 publications

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“…The structure–function relationships of HSP41 will be studied in future investigations. However, previous studies have shown heteropolysaccharides with low molecular weight to have immunomodulatory activity . In this study, HSP41 was found to be composed of three different monosaccharides with a molecular weight of 3.3 × 10 5 Da, which fits the structural characteristics of previously published polysaccharides with similar immunomodulatory activity.…”

Section: Resultssupporting

confidence: 85%

Purification, characterization and immunoregulatory activity of a polysaccharide isolated from Hibiscus sabdariffa L.

et al. 2016

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Section: Resultssupporting

confidence: 85%

Purification, characterization and immunoregulatory activity of a polysaccharide isolated from Hibiscus sabdariffa L.

et al. 2016

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“…It was reported that acid polysaccharide fractions are able to stimulate cellular responses of innate immune cells such as macrophages, dendritic cells, and NK cells [41] . The acid polysaccharides were also shown to activate these cells to secrete cytotoxic molecules such as nitric oxide and tumor necrosis factor-α in vitro [10] , [41] . Indeed, acid polysaccharides are reported to account for 74% of total KRG-WE [42] .…”

Section: Resultsmentioning

confidence: 99%

Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells

Park

Son

Aravinthan

et al. 2016

Journal of Ginseng Research

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BackgroundAlthough numerous studies of the anticancer activities of Korean Red Ginseng (KRG) have been performed, the therapeutic effect of KRG on leukemia has not been fully elucidated. In this study, we investigated the antileukemia activities of KRG and its cellular and molecular mechanisms.MethodsAn established leukemia tumor model induced by xenografted T cell lymphoma (RMA cells) was used to test the therapeutic activity of KRG water extract (KRG-WE). Direct cytotoxic activity of KRG-WE was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The immunomodulatory activities of KRG-WE were verified by immunohistochemistry, nitric oxide production assay. The inhibitory effect of KRG-WE on cell survival signaling was also examined.ResultsOrally administered KRG-WE reduced the sizes of tumor masses. Levels of apoptosis regulatory enzymes and cleaved forms of caspases-3 and -8 were increased by this extract. In addition, expression of matrix metalloproteinase-9, a metastasis regulatory enzyme, was decreased by KRG-WE treatment. The proportion of CD11c+ cells was remarkably increased in the KRG-treated group compared to the control group. However, KRG-WE did not show significant direct cytotoxicity against RMA cells.ConclusionOur results strongly suggest that the KRG might have antileukemia activity through CD11c+ cell-mediated antitumor immunity.

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“…The anomeric region of 13 C NMR (90-110 ppm) shows four main signals (Figure 3b), which were assigned based on the literature data [23,26,[38][39][40][41]58,60,61] , just like the other carbons observed in the region of 59 -85 ppm ( Table 1) 2D COSY was used to determine the proton resonance sequence (Figure 4). it is not possible to identify the sequence of hydrogens because the one-dimensional 1 H spectrum overlap them.…”

Section: Nmr Spectroscopymentioning

confidence: 99%

Polysaccharides of red alga Gracilaria intermedia: structure, antioxidant activity and rheological behavior

et al. 2018

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A sulfated polysaccharide fraction from the red alga Gracilaria intermedia (PLS) was obtained by papain digestion (60 °C, 30 min). The extract was subjected to colorimetry and turbidimetry analysis, Fourier transform infrared (FTIR) spectroscopy, 1 H, 13 C and 2 D 1 H COSY nuclear magnetic resonance (NMR) and gas chromatography/mass spectrometry analysis. Antioxidant activity tests were performed (chelation of ferrous ion, total antioxidant capacity, and scavenging of DPPH radicals); significant activity of the extract indicated that these polysaccharides may be used as non-synthetic antioxidants. The rheological behavior of aqueous polysaccharide solutions was studied at 25 ± 1 °C using steady-shear and dynamic oscillatory measurements. All the solutions analyzed showed pseudoplastic behavior and potential to act as a thickening agent, as proved through a preliminary comparison with a commercial product used for this application.

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Structural features and immunostimulating effects of three acidic polysaccharides isolated from Panax quinquefolius

Cited by 40 publications

References 34 publications

Purification, characterization and immunoregulatory activity of a polysaccharide isolated from Hibiscus sabdariffa L.

Purification, characterization and immunoregulatory activity of a polysaccharide isolated from Hibiscus sabdariffa L.

Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells

Polysaccharides of red alga Gracilaria intermedia: structure, antioxidant activity and rheological behavior

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