Structural examinations of gel-derived materials of the CaO–P2O5–SiO2 system

Łączka, M.; Cholewa‐Kowalska, Katarzyna; Kulgawczyk, K.; Klisch, M.; Mozgawa, W.

doi:10.1016/s0022-2860(99)00163-5

Cited by 34 publications

(19 citation statements)

References 10 publications

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“…The molar ratio of l -lactide to glycolide in the copolymer was 85:15 (as studied by 1 H NMR), and molecular masses of PLGA were: M n = 80 kDa and M w = 152 kDa. Bioactive glasses (S2 and A2) of the composition of: S2: 80 mol% SiO 2 –16 mol% CaO–4 mol% P 2 O 5 , and A2: 40 mol% SiO 2 –54 mol% CaO–6 mol% P 2 O 5 , were produced using the sol–gel method 19. Tetraethoxysilane (TEOS; Si(OC 2 H 5 ) 4 ), triethylphosphate (TEP; OP(OC 2 H 5 ) 3 ), and calcium nitrate tetra-hydrate (Ca(NO 3 ) 2 ·4H 2 O) were used as base components to start the sol–gel process.…”

Section: Methodsmentioning

confidence: 99%

“…Consequently, they may stimulate faster regeneration in living bone. Our earlier studies reported the production, physico-chemical, and biological properties of gel-derived bioactive glasses of the CaO–P 2 O 5 –SiO 2 system 19,27. We showed that CaO:SiO 2 ratio in these glasses influenced their physical and chemical properties and affected the growth and differentiation of bone marrow-derived cells 6,17,20.…”

Section: Introductionmentioning

confidence: 99%

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Degradation, Bioactivity, and Osteogenic Potential of Composites Made of PLGA and Two Different Sol–Gel Bioactive Glasses

et al. 2011

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We have developed poly(l-lactide-co-glycolide) (PLGA) based composites using sol–gel derived bioactive glasses (S-BG), previously described by our group, as composite components. Two different composite types were manufactured that contained either S2—high content silica S-BG, or A2—high content lime S-BG. The composites were evaluated in the form of sheets and 3D scaffolds. Sheets containing 12, 21, and 33 vol.% of each bioactive glass were characterized for mechanical properties, wettability, hydrolytic degradation, and surface bioactivity. Sheets containing A2 S-BG rapidly formed a hydroxyapatite surface layer after incubation in simulated body fluid. The incorporation of either S-BG increased the tensile strength and Young’s modulus of the composites and tailored their degradation rates compared to starting compounds. Sheets and 3D scaffolds were evaluated for their ability to support growth of human bone marrow cells (BMC) and MG-63 cells, respectively. Cells were grown in non-differentiating, osteogenic or osteoclast-inducing conditions. Osteogenesis was induced with either recombinant human BMP-2 or dexamethasone, and osteoclast formation with M-CSF. BMC viability was lower at higher S-BG content, though specific ALP/cell was significantly higher on PLGA/A2-33 composites. Composites containing S2 S-BG enhanced calcification of extracellular matrix by BMC, whereas incorporation of A2 S-BG in the composites promoted osteoclast formation from BMC. MG-63 osteoblast-like cells seeded in porous scaffolds containing S2 maintained viability and secreted collagen and calcium throughout the scaffolds. Overall, the presented data show functional versatility of the composites studied and indicate their potential to design a wide variety of implant materials differing in physico-chemical properties and biological applications. We propose these sol–gel derived bioactive glass–PLGA composites may prove excellent potential orthopedic and dental biomaterials supporting bone formation and remodeling.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradation, Bioactivity, and Osteogenic Potential of Composites Made of PLGA and Two Different Sol–Gel Bioactive Glasses

et al. 2011

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“…The band at 2800 cm -1 is assigned to the fundamental stretching vibrations of C-H bonds. The bands at 1260 and 795 cm -1 are due to the bending vibrations of Si-CH 3 bonds belonging to PDMS [34,35].…”

Section: Resultsmentioning

confidence: 99%

Sol–gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system

Czarnobaj

2010

Polym. Bull.

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Silica, silica/polydimethylsiloxane and silica/polydimethylsiloxane/ calcium xerogels were examined as polymeric carriers for the controlled release of drug-Metronidazole. Characterization assays comprised analysis of the matrix by Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET) and scanning electron microscope (SEM) techniques and further monitoring in the ultraviolet and visible light regions (UV-Vis) of the in vitro release of the drug over time. Using tetramethoxysilane (TMOS) as a precursor of silica matrix and polydimethylsiloxane (PDMS) and calcium ions as additives, xerogels with different morphology and physical properties were obtained. The applied modifications diminished the porosity and hydrophilicity of the silica matrix as well as reduced the release of drug. Based on the presented results of this study, it may be stated that applied xerogel matrices, pure silica (SiO 2 ) and modified silica (SiO 2 -CaO, SiO 2 -PDMS and SiO 2 -CaO-PDMS), could be promising candidates for the formulation in local delivery systems.

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“…All spectra present the peaks at: 3500 (3750 28 Significant differences exist for the intensity of the band only in the range 4000-2000 cm 21 for both the heated samples and nonheated ones. The intensity of the bond responsible for oscillations in the OÀ ÀH group is lower for the silica xerogels that were heated to 1208C.…”

Section: Physical Propertiesmentioning

confidence: 94%

Sol–gel processed porous silica carriers for the controlled release of diclofenac diethylamine

Czarnobaj

2008

J Biomed Mater Res

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Silica xerogels doped with diclofenac diethylamine were prepared by the sol-gel method from a hydrolysed tetraethoxysilane (TEOS) solution containing diclofenac diethylamine. Two different catalysts, drying conditions and levels of water content were used to alter the microstructure of the silica xerogels. The aim of this study was to determine the rate of Diclofenac release from the silica xerogels. This in vitro study showed that the sol-gel method is useful for entrapping Diclofenac in the pores of xerogels. It also showed that, in vitro, Diclofenac is released from the silica xerogel, through the pores, by diffusion. Base-catalysed gels proved to be much more effective than acid-catalyzed gels.

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Structural examinations of gel-derived materials of the CaO–P2O5–SiO2 system

Cited by 34 publications

References 10 publications

Degradation, Bioactivity, and Osteogenic Potential of Composites Made of PLGA and Two Different Sol–Gel Bioactive Glasses

Degradation, Bioactivity, and Osteogenic Potential of Composites Made of PLGA and Two Different Sol–Gel Bioactive Glasses

Sol–gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system

Sol–gel processed porous silica carriers for the controlled release of diclofenac diethylamine

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