Structural evidence for two-stage binding of mitochondrial ferredoxin 2 to the core iron-sulfur cluster assembly complex
Ralf Steinhilper,
Sven-A. Freibert,
Susann Kaltwasser
et al.
Abstract:Iron-sulfur (FeS) clusters are ubiquitous metallocofactors that are essential for life. In eukaryotes, FeS cluster biosynthesis begins with thede novoassembly of a [2Fe-2S] cluster by the core iron-sulfur cluster assembly (ISC) complex in the mitochondrial matrix. This complex comprises the scaffold protein ISCU2, the cysteine desulfurase subcomplex NFS1-ISD11-ACP1, the allosteric activator frataxin (FXN) and the electron donor ferredoxin 2 (FDX2). The interaction of FDX2 with the complex remains unclear. Here… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.