Structural elucidation of ubiquitin via gas-phase ion/ion cross-linking reactions using sodium-cationized reagents coupled with infrared multiphoton dissociation
Woo-Young Kang,
Arup Mondal,
Julia Bonney
et al.
Abstract:Accurate structural determination of proteins is critical to understanding their biological functions and the impact of structural disruption on disease progression. Gas-phase cross-linking mass spectrometry (XL-MS) via ion/ion reactions between multiply charged protein cations and singly charged cross-linker anions has previously been developed to obtain low-resolution structural information of proteins. This method significantly shortens experimental time relative to conventional solution-phase XL-MS, but ha… Show more
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