Structural Elucidation of New Flavanones Isolated from <i>Erythrina abyssinica</i>

Ichimaru, Momoyo; Moriyasu, Masataka; Nishiyama, Yumi; Kato, Atsushi; Mathenge, Simon G.; Juma, Fransis D.; Nganga, Joseph N.

doi:10.1021/np960440x

Cited by 37 publications

(30 citation statements)

References 8 publications

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“…1) were identified as erythrinin B, 21) abyssinin II, 22) and parvisoflavone B, 23) respectively, by comparing their physical ([a] D ) and spectroscopic (UV, MS, NMR) data with those reported in the literature. All the isolates were assayed for their inhibitory activity against PTP1B in vitro using a described method, [6][7][8][9] and the results are presented in Table 2.…”

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confidence: 99%

Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

Jang

Thương

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1-6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4-O-methyl ether (1), 2,7-dihydroxy-4-methoxy-5-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2,7-dihydroxy-3-(3-methylbut-2-enyl)

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confidence: 99%

Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

Jang

Thương

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Further still, the presence of bioactive compounds viz; abyssinoflavanone IV, V and VI posses some antimicrobial activities as reported by (Ichimaru et al, 1996).…”

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confidence: 83%

In Vitro Antimicrobial Activity of Crude Extracts of Erythrina abyssinica and Capsicum annum in Poultry Diseases Control in the South Western Agro-Ecological Zone of Uganda

Lagu¹,

Frederick²

2012

A Bird's-Eye View of Veterinary Medicine

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“…The leaves and the root decoction of the species E. secluxii are used in the treatment of malaria (Gessler et al, 1995). The stem bark of E. abysinicca is used to treat trachoma and syphilis while its root bark is used to treat malaria and colic (Ichimaru et al, 1996). Extracts of plants from this genus have proven highly bioactive (Normark and Normark, 2002); E. glauca and E. lysistemon have been reported to poses antiviral, antibacterial and estrogenic activity (Ito, 1999).…”

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confidence: 99%

Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

Ombuna¹,

Machocho²,

Keru³

et al. 2016

J. Med. Plants Res.

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The species is known from Southern Nyanza, Migori in Kenya. The extraction of the stem bark was done sequentially using organic solvents starting with the least polar; n-hexane then dichloromethane, ethyl acetate and finally the most polar methanol. Antibacterial and antifungal activities of the crude extract and that of isolated compounds from the stem bark of E. excelsa were investigated. The crude extracts had substantial activity against the tested micro-organisms. Methanol extract was highly active with inhibition zones of 15 mm against S. aureus and 14 mm against both B. subtillis and E. coli. Ethyl acetate and dichloromethane had mild activity. In antifungal test, methanol extract had highest activity of 15 mm against A. niger and 13 mm against C. albicans. Dichloromethane extract was also active with inhibition zones of 14 mm against A. niger and 12 mm against C. albicans while ethyl acetate had mild activity. A total of five compounds were isolated; glutinosalactone A (1), glutinosalactone B (2), lupinifolin (3), sitosterol (4) and 3β-stigimasterol (5). The compounds were active against the bacterial and fungal test strains used. Glutinosalactone A (1) had an activity of 15 mm against A. niger, 11 mm against both B. subtillis and S. aureas. Glutinosalactone B (2) had a high activity of 11 mm in both B. subtillis and C. albicans. and lupinifolin (3) had mild activity of 9 mm against both A. niger and C. albicans. Stigimasterol and sitosterol had mild activity of 8 mm against A. niger.

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Structural Elucidation of New Flavanones Isolated from Erythrina abyssinica

Abstract: Three new prenylated flavanones, abyssinin I (1), II (2), and III (3), have been isolated from the African medicinal plant Erythrina abyssinica, together with six known flavanones. The structural elucidation of 1−3 by spectroscopic studies is described.

Cited by 37 publications

References 8 publications

Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

In Vitro Antimicrobial Activity of Crude Extracts of Erythrina abyssinica and Capsicum annum in Poultry Diseases Control in the South Western Agro-Ecological Zone of Uganda

Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

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