Structural elucidation, in vitro DNA binding and anticancer investigations of a new specific target dinuclear Zn(II) complex

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

“…In this case, complex 2b favourably interacts with DNA compared to complex 1a and 2a. The magnitude of Stern Volmer quenching constant for complexes 1a , 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37…”

“…The magnitude of Stern Volmer quenching constant for complexes 1a, 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37 3.2.3. Viscosity measurements.…”

Repurposing the antihistamine drug bilastine as an anti-cancer metallic drug entity: synthesis and single-crystal X-ray structure analysis of metal-based bilastine and phen [Co(ii), Cu(ii) and Zn(ii)] tailored anticancer chemotherapeutic agents against resistant cancer cells

“…The incorporation of recognition domains such as intercalating moieties (phen, bipy, and dpqz) as a component of drug is known to impart superior binding to target DNA/RNAs and more potent cytotoxic response in resistant cancer cells. 19,20…”

“…The incorporation of recognition domains such as intercalating moieties ( phen, bipy, and dpqz) as a component of drug is known to impart superior binding to target DNA/RNAs and more potent cytotoxic response in resistant cancer cells. 19,20 In this work, bilastine was coordinated to a metal center via the deprotonation of a carboxylic acid functionality in the presence of triethylamine (TEA), a base, to achieve tailored metalbased anticancer drug formulation of the type [BLA( phen) 2 M (II)] + •X − , where X − = NO 3 − and ClO 4 − , and M(II) = Co(II), 1, Cu (II), 2 and Zn(II), 3. The synthesized metal-based chemotherapeutics derived from the bilastine ligand act as potent anticancer drug candidates, and to the best of our knowledge, this is the first demonstration reported in the literature.…”