Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

“…Bands visible at approximately 1428.12 and 1374.47 cm −1 were ascribed to the angle vibration of C-H bond (Chen et al, 2008;Shao et al, 2014), whilst a band at 1043.11 cm −1 was indicative of the presence of non-symmetric C-O-C stretching vibration (Ding et al, 2012). Furthermore, the characteristic absorption at around 826.75 and 874.45 cm −1 confirmed the presence of both α-and β-type glycoside bonds in the purified polysaccharides (Yu et al, 2009). All characteristic absorptions of SP1 in the FT-IR spectrum are common to all the polysaccharide (Barker, et al, 1954) To further confirm the linkage sites and sequence among residues, the 1 H NMR and 13 C NMR spectrum of SP1 were determined.…”

Structural Elucidation and Antioxidant Activity of a Polysaccharide from Mycelia Fermentation of Hirsutella sinensis Isolated from Ophiocordyceps sinensis

“…A novel polysaccharide named CBP-1 was isolated from the fruiting body of cultured Cordyceps militaris; its structural features were investigated. In the in vitro antioxidant assay, CBP-1 was found to possess the hydroxyl radical-scavenging activity with an IC 50 value of0.638 mg/mL [34].…”

Structural characterization of immunostimulating polysaccharide from cultured mycelia of Cordyceps militaris

“…Among them, Cordyceps militaris, an entomopathogenic fungus belonging to the class Ascomycetes, has been reported to have beneficial biological activities such as hypoglycemic (Kiho, Yamane, Hui, Usui, & Ukai, 1996), hypolipidemic (Yang et al, 2000), anti-inflammatory (Won & Park, 2005), antitumor (Lin & Chiang, 2008;Park et al, 2005Park et al, , 2009, anti-metastatic (Nakamura et al, 1999), immunomodulatory (Cheung et al, 2009;Kim et al, 2008), and antioxidant effect (Yu et al, 2007(Yu et al, , 2009. The fruiting bodies of wild C. militaris are expensive because of host specificity and rarity in nature.…”