Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research

Ke, Yonggang; Castro, Carlos E.; Choi, Jong Hyun

doi:10.1146/annurev-bioeng-062117-120904

Cited by 110 publications

(85 citation statements)

References 158 publications

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“…One exception, however, involves larger 3D polyhedral frameworks called nucleic acid nanoparticles (NANP). Since most NANP in the literature are comprised of natural oligonucleotides [ 72 ], they are not discussed in detail here, but their immunostimulatory properties have been documented in other reviews [ 73 ].…”

Section: General Introductionmentioning

confidence: 99%

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Ochoa

Milam

2020

Molecules

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In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications. The narrow chemical repertoire of natural nucleic acids, however, imposes restrictions on the functional scope of oligonucleotides. Initial efforts to overcome this deficiency in chemical diversity included conservative modifications to the sugar-phosphate backbone or the pendant base groups and resulted in enhanced in vivo performance. More importantly, later work involving other modifications led to the realization of new functional characteristics beyond initial intended therapeutic and diagnostic prospects. These results have inspired the exploration of increasingly exotic chemistries highly divergent from the canonical nucleic acid chemical structure that possess unnatural physiochemical properties. In this review, the authors highlight recent developments in modified oligonucleotides and the thrust towards designing novel nucleic acid-based ligands and catalysts with specifically engineered functions inaccessible to natural oligonucleotides.

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Section: General Introductionmentioning

confidence: 99%

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Ochoa

Milam

2020

Molecules

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“…Engineered nanoparticles (NPs) with unique physical and chemical properties have been widely used in catalysis (Liu and Dai, 2016;Sharma et al, 2015), electronics (Liu et al, 2017;Wu, 2017), and biomedicine (Ramos et al, 2017;Ke et al, 2018). Until now, more than 3 000 nanomaterial-based consumer products are on the market (Wei and Yan, 2016).…”

Section: Introductionmentioning

confidence: 99%

Regulating Protein Corona Formation and Dynamic Protein Exchange by Controlling Nanoparticle Hydrophobicity

Zhao

Guo

et al. 2020

Front. Bioeng. Biotechnol.

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Physiochemical properties of engineered nanoparticles (NPs) play a vital role in nanobio interactions, which are critical for nanotoxicity and nanomedicine research. To understand the effects of NP hydrophobicity on the formation of the protein corona, we synthesized four gold NPs with a continuous change in hydrophobicity ranging from −2.6 to 2.4. Hydrophobic NPs adsorbed 2.1-fold proteins compared to hydrophilic ones. Proteins with small molecular weights (<50 kDa) and negatively charge (PI < 7) constituted the majority of the protein corona, especially for hydrophobic NPs. Moreover, proteins preferred binding to hydrophilic NPs (vitronectin and antithrombin III), hydrophobic NPs (serum albumin and hemoglobin fetal subunit beta), and medium hydrophobic NPs (talin 1 and prothrombin) were identified. Besides, proteins such as apolipoprotein bound to all NPs, did not show surface preference. We also found that there was a dynamic exchange between hard protein corona and solution proteins. Because of such dynamic exchanges, protein-bound NPs could expose their surface in biological systems. Hydrophilic NPs exhibited higher protein exchange rate than hydrophobic NPs. Above understandings have improved our capabilities to modulate protein corona formation by controlling surface chemistry of NPs. These will also help modulate nanotoxicity and develop better nanomedcines.

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“…If we increase the size of the pores to allow the receiver species to pass through them with a non-zero probability, then we get the mixed configuration. A possible physical implementation is based on structural DNA nanotechnology [48], [49] which can create 3-dimensional wireframes with pores of different shapes and dimension, e.g.…”

Section: B Mixed and Partitioned Configurationsmentioning

confidence: 99%

Using Spatial Partitioning to Reduce the Bit Error Rate of Diffusion-Based Molecular Communications

Riaz

Awan

Chou

2020

IEEE Trans. Commun.

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This work builds on our earlier work on designing demodulators for diffusion-based molecular communications using a Markovian approach. The demodulation filters take the form of an ordinary differential equation (ODE) which computes the log-posteriori probability of observing a transmission symbol given the continuous history of receptor activities. A limitation of our earlier work is that the receiver is assumed to be a small cubic volume called a voxel. In this work, we extend the maximum a-posteriori demodulation to the case where the receiver may consist of multiple voxels and derive the ODE for log-posteriori probability calculation. This extension allows us to study receiver behaviour of different volumes and shapes. In particular, it also allows us to consider spatially partitioned receivers where the chemicals in the receiver are not allowed to mix. The key result of this paper is that spatial partitioning can be used to reduce bit-error rate in diffusion-based molecular communications.

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Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research

Cited by 110 publications

References 158 publications

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Regulating Protein Corona Formation and Dynamic Protein Exchange by Controlling Nanoparticle Hydrophobicity

Using Spatial Partitioning to Reduce the Bit Error Rate of Diffusion-Based Molecular Communications

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