Structural diversity, biosynthetic aspects, and LC-HRMS data compilation for the identification of bioactive compounds of Lepidium meyenii

Carvalho, Fernanda V.; Ribeiro, Paulo R.

doi:10.1016/j.foodres.2019.108615

Cited by 30 publications

(51 citation statements)

References 96 publications

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“…Macamides, known as the characteristic marker compounds of maca, consist of benzylamine and a long chain fatty acid moiety with a variable degree of unsaturation [ 22 ]. Twenty-three kinds of macamides have been reported in maca extract, among which N -benzylhexadecanamide is the most abundant compound in maca from Peru, while N -benzyl-9Z,12Z-octadecadienamide is the richest compound in the Yunnan maca [ 23 ]. In this study, we identified a novel macamide NB-EPA in maca from Yunnan.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

et al. 2021

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Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with biosynthesized NB-EPA significantly alleviates the size of cerebral infarction and improves neurobehavioral disorders after hypoxic–ischemic brain damage in neonatal mice. NB-EPA inhibited the apoptosis of neuronal cells after ischemic challenge. NB-EPA improved neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53–PUMA pathway. Taken together, these findings suggest that NB-EPA may represent a new neuroprotectant for newborns with hypoxic–ischemic encephalopathy.

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Section: Discussionmentioning

confidence: 99%

Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

et al. 2021

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“…Metabolite profiling techniques have been applied to identify potential bioactive compounds in diﬀerent biological samples [12–17] . Liquid and gas chromatography coupled with mass spectrometry (LC‐ and GC/MS) along with nuclear magnetic resonance (NMR) are the main analytical tools used in metabolite profiling studies [18–21] .…”

Section: Introductionmentioning

confidence: 99%

HPLC/HR‐MS‐Based Metabolite Profiling and Chemometrics: A Powerful Approach to Identify Bioactive Compounds from Abarema cochliacarpos

Farias

Cerqueira

Colepicolo

et al. 2021

Chemistry & Biodiversity

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Despite its importance as a medicinal plant, there is a lack of studies that assessed the chemical composition of A. cochliacarpos extracts. Herein, we used a metabolite profiling approach and chemometrics as a powerful strategy to correlate the chemical composition with the antioxidant activity of A. cochliacarpos extracts. Extracts obtained with ethyl acetate showed greater antioxidant activity and higher total phenolic content than extracts obtained with hexane. The chemical composition was assessed by HPLC/HR‐MS and it encompassed fatty alcohols, terpenoids, phenolic derivatives, lipids, carotenoid‐like compounds, alkaloids, flavonoids, polyketides, and glycerophospholipids. Chemometrics successfully differentiated not only the chemical composition of extracts in response to the nature of the extraction solvent and the botanical part used during extraction but also it allowed us to associate the chemical composition with the antioxidant activity of the extracts, which might be particularly helpful for drug discovery and development programs.

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“…Medicinal edible plants and plant-derived foods have nutritional and therapeutic benefits due to synthesis of bioactive compounds, which are responsible for the pharmacological activities and nutritional value [6][7][8][9]. These bioactive compounds encompass alkaloids, phenolic compounds (phenolic acids, flavonoids, lignans, stilbenes, and tannins), steroids, glucosides, tannins, terpenoids, and phytoalexins [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…This includes its capacity to improve spermatogenesis [25][26][27], female and male fertility , sexual performance [31][32][33], learning and memory [34][35][36], to reduce risk of osteoporosis [37,38], and to provide protection against ultraviolet radiation [39][40][41][42], as well as anti-fatigue [43][44][45][46], cell protective [47][48][49], antioxidant [50][51][52][53][54], and immunomodulatory activities [55][56][57]. Most certainly, these pharmacological activities are related to the chemical components of Lepidium meyenii [7,[58][59][60]. Therefore, this plant can be considered as nutraceutical, which encompass plants and food-based products capable of providing treatment or prevention of diseases.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

Carvalho¹,

Ferraz²,

Ribeiro³

2020

J Food Chem Nanotechnol

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Lepidium meyenii is a medicinal edible plant that have nutritional and therapeutic benefits due to synthesis of bioactive compounds. The main phytochemicals found in Lepidium meyenii can be categorized into six classes: glucosinolates and isothiocyanates, thiohydantoins, macaene and macamides, alkaloids, polysaccharides, and fatty acids. These compounds show a wide range of biological activities, which include antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and immunomodulatory activities. Hereby, the objective of this review is to provide a wide comprehension of the nutraceutical properties of Lepidium meyenii. For that, we review and critically discussed original manuscripts describing the chemical and nutritional composition, as well as biological activities of Lepidium meyenii extracts. We showed that the nutraceutical properties of the belowground part of Lepidium meyenii shows great variations that are dependent of differences of phenotype, place of cultivation, type of soil, environmental conditions, and time of harvest. Additionally, we have demonstrated that diet supplementation with Lepidium meyenii may exert several health prophylactics benefits.

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Structural diversity, biosynthetic aspects, and LC-HRMS data compilation for the identification of bioactive compounds of Lepidium meyenii

Cited by 30 publications

References 96 publications

Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

HPLC/HR‐MS‐Based Metabolite Profiling and Chemometrics: A Powerful Approach to Identify Bioactive Compounds from Abarema cochliacarpos

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

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