Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

Bridi, Henrique; Meirelles, Gabriela de Carvalho; Poser, Gilsane Lino von

doi:10.1016/j.phytochem.2018.08.002

Cited by 94 publications

(44 citation statements)

References 170 publications

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“…For example, some cytokines (IL-4 and IL-10) are regulated at the translational level, and others such as IL-1 and IL-18 at the post-translational stage [43]. These observations suggest the anti-inflammatory properties of hypermongone C. This is consistent with other studies that demonstrated compounds isolated from Hypericum genus possess potent anti-inflammatory effects [24,25,44].…”

Section: Discussionsupporting

confidence: 86%

“…Hypericum belongs to the family of Gutiferaceae (also known as Hypericaceae), a genus that features an abundance of polycyclic polyprenylated acylphloroglucinols (PPAPs) [24]. Their bioactivities are attributed to the complex and unique structure of acylphloroglucinol [25]. Medicinal plants from this genus have been used in traditional medicine due to their antibacterial, neuroprotective, and anti-inflammatory activities [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Hypermongone C Accelerates Wound Healing through the Modulation of Inflammatory Factors and Promotion of Fibroblast Migration

et al. 2019

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The physiology of wound healing is dependent on the crosstalk between inflammatory mediators and cellular components of skin regeneration including fibroblasts and endothelial cells. Therefore, strategies to promote healing must regulate this crosstalk to achieve maximum efficacy. In light of the remarkable potential of natural compounds to target multiple signaling mechanisms, this study aims to demonstrate the potential of hypermongone C, a polycyclic polyprenylated acylphloroglucinol (PPAP), to accelerate wound closure by concurrently enhancing fibroblast proliferation and migration, promoting angiogenesis, and suppressing pro-inflammatory cytokines. This compound belongs to a family of plants (Hypericum) that traditionally have been used to treat injuries. Nevertheless, the exact biological evidence to support the claims is still missing. The results were obtained using a traditional model of cell scratch assay and endothelial cell tube formation, combined with the analysis of protein and gene expression by macrophages. In summary, the data suggest that hypermongone C is a multi-targeting therapeutic natural compound for the promotion of tissue repair and the regulation of inflammation.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Hypermongone C Accelerates Wound Healing through the Modulation of Inflammatory Factors and Promotion of Fibroblast Migration

et al. 2019

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“…Results of time of addition experiments were compatible with an action on RT, while the anti-integrase (IN) activity exhibited in enzymatic assays was not significantly involved in the inhibition of viral replication. The presence of phlorogucinols in H. scruglii has confirmed their importance as chemotaxonomic markers of the Hypericum genus [87].…”

Section: Antiviral Activitymentioning

confidence: 74%

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

Sanna

Maxia

Fenu

et al. 2020

Plants

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The last decades have recorded an increase of plant-based drug discovery processes. Indeed, natural products possess a superior chemical diversity as compared to synthetic ones, leading to a renewal in searching for new therapeutic agents from the plant kingdom. In particular, since the structural variety of natural compounds reflects the biodiversity of their source organisms, regions of the world with high biodiversity and endemism deserve particular interest. In this context, Sardinia Island (Italy), with 290 endemic taxa (12% of the total flora), is expected to provide unique and structurally diverse phytochemicals for drug development. Several research groups built up a large program dedicated to the analysis of Sardinian endemic species, highlighting their peculiar features, both in respect of phytochemical and biological profiles. On this basis, the aim of this review is to provide an up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations. We documented 152 articles published from 1965 to June 2020 in which a broad range of biological activities and the identification of previously undescribed compounds have been reported, supporting their great value as sources of therapeutic agents.

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“…PAPs are chemotaxonomic markers of the genus Hypericum [30]. The majority of the isolated PAPs (compounds 3, 4, 6, 8, 9, 10, 12, and 13) have been previously described in 2 further species of the section Coridium, H. empetrifolium, and H. amblyocalyx [3][4][5], while compound 11 has been found in H. roeperianum G. W. Schimp.…”

Section: Resultsmentioning

confidence: 99%

Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential

et al. 2021

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Thirteen prenylated acylphloroglucinols (1–13), including 2 previously undescribed compounds (1) and (2), were isolated from Hypericum jovis. Their structures were elucidated by high-field NMR spectroscopy. The isolated prenylated acylphloroglucinols were evaluated for their anti-inflammatory effects in vitro through the reduction of the intercellular adhesion molecule 1 expression induced by TNF-α in the human microvascular endothelial cells 1 cell line. Compounds 3, 5, 6, 8, and 12 significantly reduced intercellular adhesion molecule 1 expression in a concentration-dependent manner with IC50 values of 16.9, 34.4, 4.0, 3.2, and 7.7 µM, respectively. In addition, compound 12 showed notable inhibitory activity on the formation of cyclooxygenase-1- and 12-lipoxygenase-derived inflammatory mediators in an ex vivo cyclooxygenase-lipoxygenase assay. Eleven further constituents were isolated (14–24), including the rare quercetin 3-O-(2-O-acetyl)-arabinofuranoside (18).

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Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

Cited by 94 publications

References 170 publications

Hypermongone C Accelerates Wound Healing through the Modulation of Inflammatory Factors and Promotion of Fibroblast Migration

Hypermongone C Accelerates Wound Healing through the Modulation of Inflammatory Factors and Promotion of Fibroblast Migration

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential

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