Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study

Schläepfer, Thomas E.; Harris, Gordon J.; Tien, Allen Y.; Peng, Luon W.; Lee, Seong; Pearlson, Godfrey D.

doi:10.1016/0925-4927(95)02634-a

Cited by 203 publications

(131 citation statements)

References 24 publications

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“…The gray-to-white matter ratio GMV/WMV was consistently lower in our study in all three groups (e.g., females in group GEN: 1.062, males: 1.025) compared to published data: Blatter et al (1995) reported GMV/WMV ratios of 1.11 for females and 1.05 for males, Schlaepfer et al (1995) found 1.21 resp. 1.16, Peters et al (1998) 1.21 resp.…”

Section: Resultssupporting

confidence: 60%

“…Following some initial studies using cranial computed tomography (CCT) (Abbott et al, 2000;Hahn et al, 1984;Schwartz et al, 1985), MRI quickly became the method of choice for data collection because MRI allows discriminating between several tissue types (Caviness et al, 1995(Caviness et al, , 1999Kennedy et al, 2003). Several studies focused on the determination of brain compartments and their gender differences (Allen et al, 2002(Allen et al, , 2003Blatter et al, 1995;Filipek et al, 1989Filipek et al, , 1994Sato et al, 2003;Schlaepfer et al, 1995) and changes of compartment volumes with age (Blatter et al, 1995;Courchesne et al, 2000;Ge et al, 2002;Giedd et al, 1996;Harris et al, 1994;Jernigan et al, 2001;Pfefferbaum et al, 1994;Resnick et al, 2003) and tried to find MRI-detectable discriminators of healthy and pathological aging in neurodegenerative diseases (Edland et al, 2002;Jenkins et al, 2000;Wolf et al, 2003Wolf et al, , 2004. Often these studies include a small sample size or a few parameters only.…”

Section: Introductionmentioning

confidence: 99%

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MRI-based volumetry of head compartments: Normative values of healthy adults

Kruggel

2006

NeuroImage

119

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The size of head compartments (head and brain volume, intracranial volume, gray and white matter volume, cerebrospinal fluid volume) and their ratios were determined on the basis of magnetic resonance images of the head acquired in a reference population of 502 healthy subjects. Age-matched subgroups were selected to reveal genderrelated differences and changes with age. Normative data are provided in the form of simple equations that allow transforming measured compartment volumes into z scores, offering the possibility to relate individual data to a larger population. D

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Section: Resultssupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

MRI-based volumetry of head compartments: Normative values of healthy adults

Kruggel

2006

NeuroImage

119

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“…Although the exact mechanisms for these differences are unknown, several potential differences have been found in brain structure (reviewed in Andreano and Cahill 2009). It has been demonstrated that women have greater volume in memory-related areas including the hippocampus (Filipek et al, 1994), caudate nucleus (Filipek et al, 1994;Murphy et al, 1996), anterior cingulate gyrus (Paus et al, 1996), and dorsolateral prefrontal cortex (Schlaepfer et al, 1995). In contrast, men have greater volume in the amygdala (Giedd et al, 1996) and paracingulate gyrus (Paus et al, 1996).…”

Section: Discussionmentioning

confidence: 95%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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“…In a study using MRI and gray-matter volume measurements (46), women were found to have higher gray-matter percentages in language-related cortical regions (in the superior temporal gyrus and in the dorsolateral prefrontal cortex).…”

Section: Discussionmentioning

confidence: 98%

Gender‐specific Differences of Hypometabolism in mTLE: Implication for Cognitive Impairments

Nickel¹,

Jokeit²,

Wunderlich³

et al. 2003

Epilepsia

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Summary:Purpose: To determine gender differences of hypometabolism and their implications for cognitive impairment in patients with medically refractory mesial temporal lobe epilepsy (mTLE).Methods: Regional cerebral glucose metabolism (rCMRGlu) was studied in 42 patients (21 male, 21 female) with either leftor right-sided mTLE (22 left, 20 right) and in 12 gender-and age-matched healthy controls during resting wakefulness and in 12 sex-and age-matched healthy controls. Clinical characteristics were balanced across the patient subgroups. All patients were subjected to neuropsychological assessment: 41 patients had histologic changes of definite or probable hippocampal sclerosis.Results: Data analysis based on pixel-by-pixel comparisons and on a laterality index of regions of interest (ROIs) showed significant depressions of the mean rCMRGlu extending beyond the mesiotemporal region and temporolateral cortex to extratemporal regions including the frontoorbital and insular cortex in mTLE patients. Extramesiotemporal hypometabolism prevailed in the male patients. Metabolic asymmetry in temporal and frontal regions was related to performance in the Trail-Making Test and WAIS-R subitems.Conclusions: Our data showed a gender-specific predominance of extramesiotemporal hypometabolism in male patients with mTLE related to abnormalities of temporal and frontal lobe functions. Key Words: FDG-PET-mTLEGender differences-Hypometabolism-Neuropsychology.Mesial temporal lobe epilepsy (mTLE) is the most common and best-defined syndrome of symptomatic localization-related epilepsy (1). Positron emission tomography (PET) using 18-fluoro-deoxyglucose (FDG-PET) was the first functional neuroimaging method allowing location of regions generating epileptiform EEG changes noninvasively (2) and has been established as a sensitive and reliable method for presurgical evaluation of TLE patients (3-5). FDG-PET has been used for lateralization of the seizure-onset zone, especially in those cases in which surface EEG and magnetic resonance imaging (MRI) provided discordant findings. However, FDG-PET revealed not only hypometabolism in the epileptogenic zone in mTLE, but also extratemporal metabolic disturbances (6-8).Accepted July 2, 2003. Address correspondence and reprint requests to Dr. R.J. Seitz at University-Hospital Düsseldorf, Department of Neurology, Moorenstrasse 5, D-40225 Düsseldorf, Germany. E-mail: seitz@neurologie.uniduesseldorf.de These "remote depressions" can affect the ipsi-and contralateral neocortical part of the temporal lobe, the frontoorbital cortex, and the thalamus. These areas are supposed to be affected secondarily by ongoing subclinical seizure activity, inhibition, and deafferentation rather than by morphologic tissue damage (8,9). The degree of hypometabolism in these regions was shown to correlate well with neuropsychological impairments such as verbal memory function or cognitive abilities (6,7).Apart from its use in the assessment of neuropsychiatric abnormalities, FDG-PET also has the capacity to provide phy...

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Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study

Cited by 203 publications

References 24 publications

MRI-based volumetry of head compartments: Normative values of healthy adults

MRI-based volumetry of head compartments: Normative values of healthy adults

The effect of sex and menstrual phase on memory formation during a nap

Gender‐specific Differences of Hypometabolism in mTLE: Implication for Cognitive Impairments

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