Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Abstract

The original article to which this Addendum refers was published in Rapid Commun. Mass Spectrom. 2005; 19: 3119–3130.

Recent (2000–2015) developments in the analysis of minor unknown natural products based on characteristic fragment information using LC–MS

“…However, many radical product ions are formed by homolytic cleavage in the analysis of natural products using ESI-MS/MS, in contradiction to the even-electron rule. Homolytic cleavage was reported for the even-electron molecular ions generated from various flavonoids (Hvattum & Ekeberg, 2003;Cuyckens & Claeys, 2004;March, Miao, & Metcalfe, 2004a;March et al, 2004bMarch et al, , 2006Parejo et al, 2004;Liu et al, 2005Liu et al, , 2009Shahat et al, 2005;Ablajan et al, 2006;Kang, Hick, & Price, 2007;Davis & Brodbelt, 2008;Zhao et al, 2008;Kite & Veitch, 2009;Vessecchi et al, 2011;Menezes et al, 2013;Xia et al, 2013), carotenoids (van Breemen, Dong, & Pajkovic, 2012Rivera, Christou, & Canela-Garayoa, 2014), alkaloids (Fabre et al, 2000;Joly et al, 2005Joly et al, , 2007Zhang et al, 2008;Deevanhxay et al, 2009;Aguiar et al, 2010), aryl a-primary amino ketones (Fornal, 2013), feruloyl quinic acids (Kuhnert et al, 2010), benzofuran derivatives (Wu et al, 2010a), cipadesin limonoids , glyceollins (Quadri et al, 2013). It seemed that the loss of a methyl radical occurs readily from methoxy groups attached to aromatic rings.…”

Tandem Mass Spectrometric Analysis of the Novel Gemini Surfactant Nanoparticle Families G12-s and G18:1-s

“…[9,23,24] Mass spectrometry (MS) is a powerful analytical tool that has been used for both qualitative and quantitative applications. [29][30][31][32] Single-stage MS and tandem mass spectrometry (MS=MS) can be utilized for structural determination and MS=MS fingerprint identification. [33] For example, using electrospray ionization (ESI), the MS=MS analysis of 18 novel cholesteryl neoglycolipids, used in liposomes-based gene delivery, resulted in the formation of specific common fingerprint fragments regardless of the nature of the sugar moiety or the spacer group that linked the carbohydrate portion to the lipid cholesteryl moiety.…”

“…[35,36] Similarly, the fragmentation routes of morphine antagonists were precisely determined using ESI-Qq-ToF MS=MS. [32] MS=MS fingerprints allow for the rapid screening of biological materials and environmental samples to determine the absence or presence of particular compounds within the tested samples. In addition, MS=MS data can be used to develop MS-based quantification methods.…”

Characterization of additives in plastics: From MS to MS10 multistep mass analysis and theoretical calculations of tris(2,4‐di‐tert‐butylphenyl)phosphate

“…Although three or four steps of mass analysis are often reported in the literature, an increase of steps is difficult to be carried out owing to a drastic decreasing of the precursor‐ion intensities with increasing number of stages of the CID experiments, as a result of the partitioning of the precursor‐ion intensity among its product ions. Thus, just few papers report on MS 6 , 20–22 MS 7 , 23,24 MS 9 , 25–27 and MS 10 experiments 28–31 . In particular, 10 mass analysis steps (MS 10 ) have been obtained by using (i) electron ionization for studying collisional activation of pyrene and anthracene, 28 and ion‐molecule chemistry of pyrene 29 ; and (ii) electrospray in positive ion mode for determining the amino acid sequence and gas‐phase ion chemistry of lithium‐coordinated valinomycin, 30 and in negative ion mode for characterizing pentasaccharides 31 …”