Structural determination of aspericins AC, new furan and pyran derivates from the marine‐derived fungus Rhizopus sp. 2‐PDA‐61, by 1D and 2D NMR spectroscopy

Abstract

Three new furan and pyran derivatives named aspericins A-C (1-3), as well as a known asperic acid (4), have been isolated from the marine-derived fungus Rhizopus sp. 2-PDA-61. The complete (1)H and (13)C NMR assignments for the new compounds were carried out using (1)H, (13)C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1-3 were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods.

Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity

“…A new compound, (S)-2, 4-dihydroxy-1-butyl (4-hydroxy) benzoate (164), from the fungus Penicillium auratiogriseum, showed cytotoxic activity against tsFT210 cells, with a maximum inhibitory rate of 8.0 µg/mL [108]. Penicillium janczewskii, obtained from a marine sample, produced 3R*,4R*-dihydroxy-4-(4'-methoxyphenyl)-3,4dihydro-2(1H)-quinolinone (165), exhibiting moderate cytotoxicity against SKOV-3 cells, with an ED 50 value of 8.1 µM [109]. A new dihydrobenzofuran derivative, awajanoran (166) (Figure 7), isolated from Acremonium sp.…”

“…Rhizopus sp. 2-PDA-61 yielded a new pyran derivative named aspericin C (282), which exhibited cytotoxicity against P388, HL-60, and BEL-7402, with IC 50 values of 14.6, 7.1, and 24.2 µM, while VP16, a positive control, inhibited these cell lines, with IC 50 values ranging from 0.064 to 1.025 µM [165].…”

New Marine Natural Products of Microbial Origin from 2010 to 2013

“…呋喃和吡喃类 化合物 642～644 来自根霉 Rhizopus sp. 2-PDA-61(草苔 虫, 胶州湾), 其中化合物 644 对 HL-60 和 BEL-7420 的 IC 50 分别为 7.1 和 24.2 μmol/L [248] . 二萜类糖苷 645～649 来自枝顶孢霉菌 Acremonium striatisporum(海参, 日本 海) [249] .…”