Abstract:Ferrous iron (Fe2+) is required for the growth and virulence of many pathogenic bacteria, includingVibrio cholerae(Vc), the causative agent of the disease cholera. For this bacterium, Feo is the primary system that transports Fe2+into the cytosol. FeoB, the main component of this system, is regulated by a soluble cytosolic domain termed NFeoB. Recent reanalysis has shown that NFeoBs can be classified as either GTP-specific or NTP-promiscuous, but the structural and mechanistic bases for these differences were … Show more
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