Structural deficits in the emotion circuit and cerebellum are associated with depression, anxiety and cognitive dysfunction in methadone maintenance patients: A voxel-based morphometric study

Lin, Wei Che; Chou, Kun Hsien; Chen, Hsiu-Ling; Huang, Chu-Chung; Lu, Cheng Hsien; Li, Shau Hsuan; Wang, Ya Ling; Cheng, Yu; Lin, Ching Po; Chen, Chien Chih

doi:10.1016/j.pscychresns.2011.05.009

Cited by 56 publications

(33 citation statements)

References 63 publications

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“…Relative to cocaine-induced changes on GMV, the structural alterations in the PFC are less pronounced in heroin addicts (Verdejo-García et al , 2007), further indicating that the effects of heroin and cocaine consumption are distinct. Furthermore, significant reductions in GMV of the right IFG have also been reported in heroin-dependent individuals on methadone-maintenance treatment (Lin et al , 2012; Lyoo et al , 2006). Based on these findings, we may speculate that our fMRI findings are partly mediated by structural alterations in the IFG as a result of long-term heroin use.…”

Section: Discussionmentioning

confidence: 84%

Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Schmidt

Walter

Gerber

et al. 2013

Neuropsychopharmacol

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Impairments in inhibitory control and in stimulus-driven attention are hallmarks of drug addiction and are associated with decreased activation in the right inferior frontal gyrus (IFG). Although previous studies indicate that the response inhibition function is impaired in abstinent heroin dependents, and that this is mediated by reduced IFG activity, it remains completely unknown whether and how an acute dose of heroin modulates IFG activity during cognitive control in heroin-dependent patients. This study investigates the acute effects of heroin administration on IFG activity during response inhibition and stimulus-driven attention in heroin-dependent patients. Using a cross-over, double-blind, placebo-controlled design, saline and heroin were administered to 26 heroin-dependent patients from stable heroin-assisted treatment, while performing a Go/No–Go event-related functional magnetic resonance imaging task to assess right IFG activity during motor response inhibition, as well as during oddball-driven attention allocation. Relative to saline, heroin significantly reduced right IFG activity during both successful response inhibition and oddball-driven attention allocation, whereas it did not change right IFG activity during response inhibition after correction for the effect of attention allocation. These heroin-induced effects were not related to changes in drug craving, state anxiety, behavioral performance, or co-consumption of psychostimulant drugs. This study demonstrates that heroin administration acutely impairs stimulus-driven attention allocation, as indicated by reduced IFG activity in response to infrequently presented stimuli, and does not specifically modulate IFG activity during response inhibition.

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Section: Discussionmentioning

confidence: 84%

Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Schmidt

Walter

Gerber

et al. 2013

Neuropsychopharmacol

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“…For instance, depression is ubiquitous among patients receiving MMT, although different studies report a wide variety of prevalence rates (11) and depressive disorders are associated with interference control (12). A voxel-based morphometric study revealed that MMT patients have structural deficits in the emotion control circuit and cerebellum, which are associated with depression, anxiety and cognitive dysfunction (13). Using diffusion tensor imaging, MMT patients were found to have more memory and emotional deficits than healthy subjects (7).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal behavioral and fMRI‑based assessment of inhibitory control in heroin addicts on methadone maintenance treatment

Zhang

et al. 2018

Exp Ther Med

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Abstract. The objective of the present study was to determine whether methadone maintenance treatment (MMT) in heroin-dependent patients affects inhibitory control, whether any MMT-induced changes correlate with methadone dose and MMT duration, and whether these changes depend on the psychological characteristics of patients, such as depression, anxiety and impulsivity. Response inhibition in the GO/NO-GO test was combined with functional magnetic resonance imaging (fMRI) scanning data to examine whether MMT affects inhibitory control in 21 heroin-addicted patients who had already undergone at least three months of MMT. Patients were evaluated one year prior to and after the MMT period. Participants exhibited no difference in their GO/NO-GO reaction time and accuracy rate, or in their false alarm rate under NO-GO conditions. However, increased activation was detected in numerous brain regions in their 12-month fMRI scans, although these were not in the frontal-striatal loop. Increased fMRI activation in the left precentral gyrus and superior temporal gyrus were negatively correlated with the daily methadone dose and total methadone dose during the one-year study period. In conclusion, these results suggested that MMT over one year does not significantly change the behavioral indicators of inhibitory control function in heroin-dependent patients. The increase in activation leads to the hypothesis that MMT over one year may increase cognitive inhibitory control, which may be the result of the combined negative effect of methadone and the positive effect of functional recovery after withdrawal of heroin.

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“…Heroin dependence can cause depressive symptoms (Lin et al, 2012). On the other hand, depressive symptoms in individuals with heroin dependence may lead to higher relapse rates and suicidal tendencies (Darke & Ross, 2002;Trivedi, Hollander, Nutt & Blier, 2008), poor physical health (Teesson et al, 2005), impaired psychosocial functioning, and diminished quality of life (Kennedy & Paykel, 2004 Furthermore, heroin dependence and major depressive disorder has reported to cause cognitive disruptions (Garavan & Hester, 2007), which are associated with gray matter volume (GMV) disruptions .…”

Section: Introductionmentioning

confidence: 99%

“…The heterogeneity of these results might be related to differences in clinical characteristics of the sample such as illness duration, severity, comorbidity and medication (Bora, Fornito, Pantelis & Yucel, 2012). For instance, a recent MRI study using Voxel-based morphometry (VBM) analysis, characterized structural deficits in heroin users on methadone treatment with co-morbid depression (Lin et al, 2012). In comparison to healthy controls, this study found diminished GMV in medial frontal gyrus, post-central gyrus, inferior frontal gyrus, sub-colossal cingulate gyrus in the left hemisphere, and right cerebellar declive.…”

Section: Introductionmentioning

confidence: 99%

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

Mwansisya¹,

Zhang²,

Wang³

et al. 2016

Int J Emerg Ment Health

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Structural deficits in the emotion circuit and cerebellum are associated with depression, anxiety and cognitive dysfunction in methadone maintenance patients: A voxel-based morphometric study

Cited by 56 publications

References 63 publications

Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Longitudinal behavioral and fMRI‑based assessment of inhibitory control in heroin addicts on methadone maintenance treatment

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

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