Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study

Koutsouleris, Nikolaos; Gaser, Christian; Jäger, Markus; Bottlender, Ronald; Frodl, Thomas; Holzinger, S.; Schmitt, Gisela; Zetzsche, T.; Burgermeister, Bernhard; Scheuerecker, Johanna; Born, Christine; Reiser, Maximilian; Möller, Hans‐Jürgen; Meisenzahl, Eva

doi:10.1016/j.neuroimage.2007.10.029

Cited by 166 publications

(137 citation statements)

References 73 publications

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“…It is interesting to note that this interaction was more prominent in the paranoid rather than the negative subgroup, even though prefrontal deficits are thought to be most prevalent in the latter subgroup of patients. 5,15,37 It appears that this finding does not contradict the general association of negative symptoms with prefrontal structural changes (or progression) because we need to consider the fact that negative symptoms-although most prominent in that 1 subgroup-were prevalent in all the 3 schizophrenia subgroups to varying degrees.…”

Section: Discussionmentioning

confidence: 86%

Aging Effects on Regional Brain Structural Changes in Schizophrenia

Nenadić

Sauer

Smesny

et al. 2011

Schizophrenia Bulletin

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Background: Although mostly conceptualized as a neurodevelopmental disorder, there is an increasing interest in progressive changes of cognitive deficits and brain structure and function in schizophrenia across the life span. Methods: In this study, we investigated age-related changes in regional gray matter using voxel-based morphometry in a sample of 99 patients (age range 18-65 years) with Diagnostic and Statistical Manual of Mental Disorders-IV schizophrenia and 113 healthy controls (age range 19-59 years) using a cross-sectional design. Results: We found steeper age-related decline in gray matter in patients in a cluster comprising the left superior temporal cortex and adjacent inferior parietal lobule. We then divided the schizophrenia sample in 3 subgroups based on a 3-factor model of psychopathology ratings. Age-related changes were markedly different in each of the 3 subgroups (compared with healthy controls). While patients with predominantly paranoid symptoms showed stronger agerelated progression in the left superior temporal cortex and right inferior frontal gyrus, those of the disorganized subgroup had stronger gray matter loss in the left lateral cerebellum, while the predominantly negative subgroup showed minor effects in the left superior temporal gyrus. Conclusions: Our findings show that differences in brain structural changes associated with aging diverge between schizophrenia patients and healthy subjects and that different subgroups within a patient sample might be at higher risk of age-related regional gray matter loss.

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Section: Discussionmentioning

confidence: 86%

Aging Effects on Regional Brain Structural Changes in Schizophrenia

Nenadić

Sauer

Smesny

et al. 2011

Schizophrenia Bulletin

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“…'s 38 review of meta‐analyses of VBM studies of schizophrenia. On the other hand, the view that negative symptoms (or other schizophrenic symptoms) have brain structural correlates is far from clearly established 41, 42, 43, 44, 45, 46, 47.…”

Section: Discussionmentioning

confidence: 99%

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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ObjectiveBrain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.MethodForty‐five patients meeting DSM‐IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel‐based morphometry (VBM).ResultsAnalyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five.ConclusionThe findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.

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“…123 It is worth noting that most studies reporting clinical correlation of insular deficits included patients taking antipsychotic medications. Antipsychotics not only reduce the severity of psychotic symptoms (especially reality distortion and disorganization), but also affect the brain structure as discussed previously.…”

Section: Correlation Of Insular Deficits With Clinical Symptomsmentioning

confidence: 99%