Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

Grossi, Dario; Soricelli, Andrea; Ponari, Marta; Salvatore, Elena; Quarantelli, Mario; Prinster, Anna; Trojano, Luigi

doi:10.1016/j.cortex.2012.09.010

Cited by 63 publications

(43 citation statements)

References 79 publications

(86 reference statements)

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“…Our findings in this study and a review of the literature support a right hemisphere face-processing network (Busigny et al, 2009; Haxby et al, 2000; Hudson and Grace, 2000; Takahashi et al, 1995) that begins in the occipital face area and fusiform face area with feature detection and configural binding into a face, as shown by our patients with DP. The network ends in the right ATL at the personal identity nodes level with the linking of perceptual representations to semantic memories or person knowledge, as shown by our patients with SD (Gobbini and Haxby, 2006, 2007; Grossi et al, 2014; Nakamura et al, 2000; Shah et al, 2001). The literature further suggests an intermediate disturbance of face memory familiarity in the right ATL or its connections.…”

Section: Discussionmentioning

confidence: 66%

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Mendez

Ringman

Shapira

2015

Cognitive and Behavioral Neurology

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Background Developmental prosopagnosia (DP) and semantic dementia (SD) may be the two most common neurologic disorders of face processing, but their main clinical and pathophysiologic differences have not been established. To identify those features, we compared patients with DP and SD. Methods Five patients with DP, five with right temporal-predominant SD, and ten normal controls underwent cognitive, visual perceptual, and face-processing tasks. Results Although the patients with SD were more cognitively impaired than those with DP, the two groups did not differ statistically on the visual perceptual tests. On the face-processing tasks, the DP group had difficulty with configural analysis and they reported relying on serial, feature-by-feature analysis or awareness of salient features to recognize faces. By contrast, the SD group had problems with person knowledge and made semantically related errors. The SD group had better face familiarity scores, suggesting a potentially useful clinical test for distinguishing SD from DP. Conclusions These two disorders of face processing represent clinically distinguishable disturbances along a right hemisphere face-processing network: DP, characterized by early configural agnosia for faces, and SD, characterized primarily by a multimodal person knowledge disorder. We discuss these preliminary findings in the context of the current literature on the face-processing network; recent studies suggest an additional right anterior temporal, unimodal face familiarity-memory deficit consistent with an “associative prosopagnosia.”

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Section: Discussionmentioning

confidence: 66%

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Mendez

Ringman

Shapira

2015

Cognitive and Behavioral Neurology

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“…In one case study, destruction of the ILF caused deficits in identifying facial emotions, presumably due to destruction of the extrastriate-amygdala branch (Philippi, Mehta, Grabowski, Adolphs, & Rudrauf, 2009). In another case, degradation of the right ILF in a variant of frontotemporal dementia called progressive prosopagnosia correlated with face identification deficits (Grossi et al, 2012). These results are compatible with findings showing that white matter scarring of the ILF in multiple sclerosis correlates with prosopagnosia as well as object recognition deficits (Yamasaki et al, 2004).…”

Section: Connectivity Of the Ventral Anterior Temporal Face Areamentioning

confidence: 99%

“…Diffusion imaging studies have also reported associations between the structural integrity of the ILF, and in some cases the IFOF, and face recognition abilities (Tavor et al, 2013; Thomas et al, 2008). In addition, two studies have shown that congenital prosopagnosics, relative to controls, exhibit reduced structural integrity of the right ILF (Thomas et al, 2008; Grossi et al, 2012) and the right IFOF (Thomas et al, 2008) and that this predicts face-recognition impairments (Thomas et al, 2008). In addition to face recognition, the ILF appears to play an important role in object recognition (Coello, Duvaux, De Benedictis, Matsuda, & Duffau, 2013; Gil-Robles et al, 2013; Ortibus et al, 2012; Shinoura et al, 2013) and visual recognition of words (Epelbaum et al, 2008; Gil-Robles et al, 2013; Yeatman, Dougherty, Ben-Shachar, & Wandell, 2012).…”

Section: Connectivity Of the Ventral Anterior Temporal Face Areamentioning

confidence: 99%

Beyond the FFA: The role of the ventral anterior temporal lobes in face processing

2014

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Extensive research has supported the existence of a specialized face-processing network that is distinct from the visual processing areas used for general object recognition. The majority of this work has been aimed at characterizing the response properties of the fusiform face area (FFA) and the occipital face area (OFA), which together are thought to constitute the core network of brain areas responsible for facial identification. Although accruing evidence has shown that face-selective patches in the ventral anterior temporal lobes (vATLs) are interconnected with the FFA and OFA, and that they play a role in facial identification, the relative contribution of these brain areas to the core face-processing network has remained unarticulated. Here we review recent research critically implicating the vATLs in face perception and memory. We propose that current models of face processing should be revised such that the ventral anterior temporal lobes serve a centralized role in the visual face-processing network. We speculate that a hierarchically organized system of face processing areas extends bilaterally from the inferior occipital gyri to the vATLs, with facial representations becoming increasingly complex and abstracted from low-level perceptual features as they move forward along this network. The anterior temporal face areas may serve as the apex of this hierarchy, instantiating the final stages of face recognition. We further argue that the anterior temporal face areas are ideally suited to serve as an interface between face perception and face memory, linking perceptual representations of individual identity with person-specific semantic knowledge.

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“…The ILF forms a ventral occipitotemporal processing pathway with the inferior frontooccipital fasciculus (IFOF), which is considered to be involved in visual identification and pattern discrimination, connecting regions of the core system of facial recognition (Table 3). 6,35,72 Removing the insular cortex and extreme capsule, the anterior part of the AF, and the MdLF exposes the external capsule and corona radiata. The external capsule with its fanlike shape divides into 2 parts: a dorsal part, formed by the claustrocortical fibers, and a ventral part, formed by the IFOF and uncinate fasciculus (UF).…”

Section: Fiber Tracts Of the Cerebrummentioning

confidence: 99%

“…6,35,86,108,124 A modification of the transtemporal approach that includes a cortical incision through the posterior part of the middle temporal gyrus to reach lesions in the posterior one-third of the temporal horn and the atrium carries a high risk of visual and language disconnection syndromes if the AF and optic radiation are damaged ( Fig. 16; Tables 1 and 2).…”

Section: 573112mentioning

confidence: 99%

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

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S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

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Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus

Cited by 63 publications

References 79 publications

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia

Beyond the FFA: The role of the ventral anterior temporal lobes in face processing

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

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