Structural Chemistry of Zeolitic Imidazolate Frameworks

Zheng, Zhiling; Rong, Zichao; Nguyen, Ha L.; Yaghi, Omar M.

doi:10.1021/acs.inorgchem.3c02322

Cited by 11 publications

(9 citation statements)

References 89 publications

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“…They are all constructed from the same basic node of In 3+ chelated by three hydroxamate groups from three TDHA ligands, but variations in coordination modes and (θ) angles led to very different outcomes. The robust formation of identical Ga/In(hydroxamate) 3 nodes in these MOMs suggested that these moieties were stable and favored, concurring with previously reported hydroxamate-chelated Group 13 metal complexes. , Moreover, similar phenomena were recorded in the MOF literature where identical PBUs/SBUs could be interconnected by ligands of the same basic geometry to form diverse topologies. − …”

Section: Resultssupporting

confidence: 88%

Structural Diversity in Ga/In-Hydroxamate Metal–Organic Materials

Wu,

Qin,

Duan

et al. 2024

Inorg. Chem.

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Developing metal–organic materials (MOMs) with chemical robustness is a prerequisite to exploring their intriguing properties and applications. As part of a continuing effort to construct robust MOMs featuring chelated building units, here we introduce a “bent” thiophene-2,5-dihydroxamate ligand with multiple intrinsic conformations when it is used as a chelating linkage. This approach should further diversify the coordination chemistry in hydroxamate-based MOM structures without compromising the stability. In combination with Group 13 metals Ga/In to ensure homoleptic metal vertices, we report the successful crystallization of four MOMs with diverse structures and dimensionalities: SUM-81 as a 0D metal–organic polyhedron (MOP), SUM-82 as a 2D MOF with an fes topology, SUM-83 and SUM-84 as distinct 1D coordination polymers with shapes mimic stairs and mesh tubes, respectively. As these structures indeed contain the aforementioned different ligand conformations and combinations thereof, these results expand our understanding of the coordination chemistry of hydroxamates. To demonstrate the potential applicability of hydroxamate-chelated robust MOMs, the permanently porous SUM-81 MOP was successfully incorporated in a series of mixed matrix membranes for CO2/N2 separation, showing impressive performances.

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Section: Resultssupporting

confidence: 88%

Structural Diversity in Ga/In-Hydroxamate Metal–Organic Materials

Wu,

Qin,

Duan

et al. 2024

Inorg. Chem.

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“…ZIFs are a subclass of metal–organic framework MOF materials composed of transition-metal ions and nitrogen-containing heterocyclic imidazole or purine organic ligands. ZIFs exhibit high porosity, relatively low cytotoxicity, and instability under acidic conditions . Zhang et al utilized pH-sensitive material ZIF-67 as a carrier to construct a pH-responsive nitrile imine nanodelivery system for intelligent and precise control of citrus gray mold disease .…”

Section: Resultsmentioning

confidence: 99%

“…ZIFs exhibit high porosity, relatively low cytotoxicity, and instability under acidic conditions. 24 Zhang et al utilized pH-sensitive material ZIF-67 as a carrier to construct a pH-responsive nitrile imine nanodelivery system for intelligent and precise control of citrus gray mold disease. 25 Therefore, it is worthwhile to investigate the specific release behavior of GEM by constructing a pH-responsive delivery system based on ZIF-67.…”

Section: Resultsmentioning

confidence: 99%

Targeted Delivery of Gemcitabine for Precision Therapy of Cholangiocarcinoma Using Hyaluronic Acid-Modified Metal–Organic Framework Nanoparticles

Long,

Peng,

Yang

et al. 2024

ACS Omega

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Chemotherapy is widely recognized as an important approach for the treatment of cholangiocarcinoma. Gemcitabine (GEM) has been considered a first-line drug for treating cholangiocarcinoma due to its ability to effectively inhibit the proliferation, migration, and invasion of liver cancer cells. However, the systemic toxicity, premature degradation, and lack of tumortargeting properties of GEM limit its application in cholangiocarcinoma chemotherapy. Additionally, precise targeted delivery of GEM is necessary to align with the current concept of precision medicine. In this study, considering the overexpression of hyaluronic acid (HA) receptors (CD44) on cholangiocarcinoma cells, we

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“…Because of its high surface area, excellent stability, and low cytotoxicity, zeolitic imidazolate framework-8 (ZIF-8) composed of Zn 2+ coordinated with 2-methylimidazole (2-mIM) is one of the most popular and well-studied MOF materials. 23–26 In this study, ZIF-8 was selected as the candidate MOF material, and the controlled co-precipitation strategy with polyvinylpyrrolidone (PVP) as the capping agent was adopted. 2,27 Of note, a low 2-mIM/Zn molar ratio of 8 : 1 was used to prepare the KmCR2@ZIF biocomposites, as previous studies indicated that biocomposites synthesized with a low 2-mIM/Zn molar ratio possessed higher enzyme loadings and specific activities than those fabricated with a high 2-mIM/Zn molar ratio.…”

Section: Resultsmentioning

confidence: 99%