Structural characterization of the Sel1‐like repeat protein LceB from Legionella pneumophila
Tiffany V. Penner,
Neil Lorente Cobo,
Deepak T. Patel
et al.
Abstract:Legionella are freshwater Gram‐negative bacteria that in their normal environment infect protozoa. However, this adaptation also allows Legionella to infect human alveolar macrophages and cause pneumonia. Central to Legionella pathogenesis are more than 330 secreted effectors, of which there are 9 core effectors that are conserved in all pathogenic species. Despite their importance, the biochemical function of several core effectors remains unclear. To address this, we have taken a structural approach to chara… Show more
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