Structural characterization of surface glycans from Clostridium difficile

Reid, Christopher W.; Vinogradov, Evgeny; Li, Jianjun; Jarrell, Harold C.; Logan, Susan M.; Brisson, Jean‐Robert

doi:10.1016/j.carres.2012.02.002

Cited by 66 publications

(71 citation statements)

References 57 publications

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“…This cell biological function, i.e., the markings of new and old peptidoglycan or of discrete subcellular sites, may explain the essential contributions of teichoic acids to bacterial growth. Technological advances such as NMR and mass spectrometry have provided the means of identifying and characterizing the structures of new amphiphiles from Gram-positive bacteria (44,135). Yet we remain unable to build models for the synthesis of many different types of LTA molecules.…”

Section: Discussionmentioning

confidence: 99%

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

2014

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Section: Discussionmentioning

confidence: 99%

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

2014

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“…A Gal-Gal-GroP-repeating unit was detected in Lactococcus garvieae (formerly Streptococcus lactis ) [22, 27, 29, 31,32,33,34]. Several rare repeating units have been identified in Clostridium difficile [35], Clostridium innocuum ATCC 14501 T [34], Streptococcus oralis Uo5 [36], and Streptococcus pneumoniae R6 (ATCC BAA-225) [34, 37,38,39,40] and R36A (ATCC 12214) [37] (see Table 1 for detailed structures).…”

Section: Structural Diversity In Ltasmentioning

confidence: 99%

Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria

Shiraishi

Yokota

Fukiya

et al. 2016

Bioscience of Microbiota, Food and Health

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Bacterial cell surface molecules are at the forefront of host-bacterium interactions. Teichoic acids are observed only in Gram-positive bacteria, and they are one of the main cell surface components. Teichoic acids play important physiological roles and contribute to the bacterial interaction with their host. In particular, lipoteichoic acid (LTA) anchored to the cell membrane has attracted attention as a host immunomodulator. Chemical and biological characteristics of LTA from various bacteria have been described. However, most of the information concerns pathogenic bacteria, and information on beneficial bacteria, including probiotic lactic acid bacteria, is insufficient. LTA is structurally diverse. Strain-level structural diversity of LTA is suggested to underpin its immunomodulatory activities. Thus, the structural information on LTA in probiotics, in particular strain-associated diversity, is important for understanding its beneficial roles associated with the modulation of immune response. Continued accumulation of structural information is necessary to elucidate the detailed physiological roles and significance of LTA. In this review article, we summarize the current state of knowledge on LTA structure, in particular the structure of LTA from lactic acid bacteria. We also describe the significance of structural diversity and biological roles of LTA.

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“…We were unable to isolate staphylococcal mutants with resistance against compound 1771, suggesting that LTA synthesis may display target attributes similar to peptidoglycan synthesis. Some Gram-positive bacteria, for example, C. difficile and S. pneumoniae, synthesize LTA with distinct phosphate-polymer structures (42,43); however, their mechanisms of synthesis and possible inhibition by compound 1771 are not yet known. Future work must develop compound 1771 further to generate molecules that are stable in mammalian tissues and display antibiotic activity against many different bacteria.…”

Section: Selecting For S Aureus Variants With Increased Resistance Tmentioning

confidence: 99%

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

Richter

Elli

Kim

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

127

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The current epidemic of infections caused by antibiotic-resistant Gram-positive bacteria requires the discovery of new drug targets and the development of new therapeutics. Lipoteichoic acid (LTA), a cell wall polymer of Gram-positive bacteria, consists of 1,3-polyglycerol-phosphate linked to glycolipid. LTA synthase (LtaS) polymerizes polyglycerol-phosphate from phosphatidylglycerol, a reaction that is essential for the growth of Gram-positive bacteria.

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Structural characterization of surface glycans from Clostridium difficile

Cited by 66 publications

References 57 publications

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

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