Structural characterization of phytochemical content, antibacterial, and antifungal activities of Juglans regia L. leaves cultivated in Algeria

Bennacer, Amel; Fatma, Sahir-Halouane; Aitslimane-Aitkaki, Sabrina; Oukali, Zahia; Oliveira, Ivo; Rahmouni, Naima; Aissaoui, Mohammed

doi:10.1016/j.bcab.2022.102304

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…Finally, comparing our antioxidant activity results with other studies, we found that several plant extracts exhibited remarkable antioxidant potentials, surpassing the activity of the synthetic antioxidant Trolox [41][42][43]. The high content of phenolic acids in certain samples, such as MEC, JUR, and SAN, could be linked to their superior antioxidant performance [38].…”

Section: Bioactive Propertiessupporting

confidence: 67%

Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives

Deus

Fernandes

Molina

et al. 2023

Plants

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Consumer demand for natural and healthier products has led to an increasing interest in the bioactive and therapeutic properties of plant extracts. In this study, we evaluated the phenolic compounds profile, bioactivities, and toxicities of plant extracts from eight European flora species, including Calendula officinalis L., Calluna vulgaris (L.) Hull, Hippophae rhamnoides L., Juglans regia L., Mentha cervina L., Rubus idaeus L., Sambucus nigra L., and Vitis vinifera L. The aim was to identify potential preservatives of natural origin. Phenolic compounds were identified by HPLC-DAD-ESI-MS. Caffeic acid derivatives, ellagitannins, flavonols, and flavones were the major phenolic compounds identified. The total phenolic content varied from 16.0 ± 0.2 (V. vinifera) to 123 ± 2 mg/g (H. rhamnoides) of dry extract. All extracts showed antioxidant potential and exhibited activity against some of the microorganisms tested. S. nigra showed the highest activity in the inhibition of oxidative hemolysis (OxHLIA) assay and H. rhamnoides, notably, had the lowest IC50 values in TBARS and DPPH assays, as well as the lowest minimum inhibitory concentration (MIC) values. Regarding in vitro cytotoxicity, in tumor and non-tumor cell lines, although some extracts revealed toxicity against normal cells, it was found that the samples C. vulgaris, V. vinifera and R. idaeus might be used against tumor cells since the active concentration is much lower than the one causing toxicity. In vivo acute toxicity tests using Artemia franciscana suggest low toxicity for most extracts, with LC50 > 400 mg/L. These results showed the potential of the studied extracts as natural preservatives, given their richness in compounds with bioactive properties, highlight their potential value to the production chain.

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Section: Bioactive Propertiessupporting

confidence: 67%

Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives

Deus

Fernandes

Molina

et al. 2023

Plants

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“…Bennacer et al [ 40 ] presented that in vitro the tannic extract from walnut leaves showed a high antifungal activity against A. terreus, A. ochraceus , and A. brasilliensis with an inhibition percentage of 77% for a concentration of 40 mg/mL. Wianowska et al [ 94 ] demonstrated that walnut green shell extracts contain a substance called juglone, which exhibits an inhibitory activity for A. alternata of 45%.…”

Section: Health Benefits and Applications Of Walnut By-products ( ...mentioning

confidence: 99%

“…According to Medic et al [35], who performed the extraction of 0.25 g of leaf powder with methanol in an extract ratio of 1:30 (w/v) leaves: methanol using ultrasonication for 60 min and analyzed the extracts via HPLC-MS, and other research [36][37][38][39][40][41][42], walnut leaves contain a large amount of compounds from the class of hydroxycinnamic acids (neochlorogenic acid and 3-p-coumaroylquinic acid), flavonoids ((+) catechin, procyanidin dimers, and quercetin derivatives), and naphthoquinones (hydrojuglone derivatives, juglone, and sdihydroxytetralone hexoside) (Table 2). Green walnut shell extracts can be obtained using several extraction methods.…”

Section: Chemical Composition Of Walnut Leavesmentioning

confidence: 99%

Walnut By-Products and Elderberry Extracts—Sustainable Alternatives for Human and Plant Health

Sandu-Bălan (Tăbăcariu),

Ifrim,

Patriciu

et al. 2024

Molecules

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A current alternative for sustainable development through green chemistry is the replacement of synthetic compounds with natural ones through the superior capitalization of natural resources, with numerous applications in different fields. The benefits of walnuts (Juglans regia L.) and elderberries (Sambucus nigra L.) have been known since ancient times, due to the presence of phytochemicals such as flavonoids, polyphenols, carotenoids, alkaloids, nitrogen-containing compounds, tannins, steroids, anthocyanins, etc. These active compounds have multiple biological activities for human health, including benefits that are antibacterial, antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, antihypertensive, neuroprotective, etc. Like other medicinal plants, the walnut and the elderberry possess important phytosanitary properties (antibacterial, antifungal, and insecticidal) and their extracts can also be used as environmentally safe biopesticides, with the result that they constitute a viable and cheap alternative to environmentally harmful synthetic products. During recent years, walnut by-products and elderberries have attracted the attention of researchers, and investigations have focused on the species’ valuable constituents and active properties. Comparing the information from the literature regarding the phytochemical profile and biological activities, it is highlighted that, apart from the predominant specific compounds, the walnut and the elderberry have common bioactive compounds, which come from six classes (phenols and derivatives, flavonoids, hydroxycinnamic acids, tannins, triterpenoids, and phytosteroids), and act on the same microorganisms. From this perspective, the aim of this review is to provide an overview of the bioactive compounds present in the different constitutive parts of walnut by-products and elderberries, which present a specific or common activity related to human health and the protection of agricultural crops in the context of sustainable development.

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“…Polyphenols have been demonstrated to exhibit properties which influence the key neuronal signaling pathways in memory and learning. Based on obesity, hypercholesterolemia, and oxidative stress, walnut polyphenolic extracts improved learning by 42% and memory in hypercholesterolemic rats [ 109 ]. A walnut diet containing 6% walnut oil protected male rats from neurotoxicity caused by the chemotherapeutic drug cisplatin, according to another study.…”

Section: Pharmacological Applicationsmentioning

confidence: 99%

Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds

Bhat

Shakeel

Rafiq

et al. 2023

Life

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Juglans regia Linn. is a valuable medicinal plant that possesses the therapeutic potential to treat a wide range of diseases in humans. It has been known to have significant nutritional and curative properties since ancient times, and almost all parts of this plant have been utilized to cure numerous fungal and bacterial disorders. The separation and identification of the active ingredients in J. regia as well as the testing of those active compounds for pharmacological properties are currently of great interest. Recently, the naphthoquinones extracted from walnut have been observed to inhibit the enzymes essential for viral protein synthesis in the SARS-CoV-2. Anticancer characteristics have been observed in the synthetic triazole analogue derivatives of juglone, and the unique modifications in the parent derivative of juglone have paved the way for further synthetic research in this area. Though there are some research articles available on the pharmacological importance of J. regia, a comprehensive review article to summarize these findings is still required. The current review, therefore, abridges the most recent scientific findings about antimicrobial, antioxidant, anti-fungal, and anticancer properties of various discovered and separated chemical compounds from different solvents and different parts of J. regia.

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Structural characterization of phytochemical content, antibacterial, and antifungal activities of Juglans regia L. leaves cultivated in Algeria

Cited by 6 publications

References 32 publications

Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives

Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives

Walnut By-Products and Elderberry Extracts—Sustainable Alternatives for Human and Plant Health

Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds

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