Structural characterization of pectic polysaccharides from Amaranth caudatus leaves and the promotion effect on hippocampal glucagon-like peptide-1 level

Rang, Yifeng; Liu, Huan; Cheng, Xiang; Li, Weiye; Shi, Jian; Ou, Genghua; Huang, Huiying; Chen, Congying; Xiao, Xueman; Liu, Chunhong

doi:10.1016/j.ijbiomac.2023.124967

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…Thus, Ord-TPS and PCSe-TPS intervention could up-regulate the relative abundance of unclassified Oscillospiraceae to promote butyrate production and then enhance the secretion of GLP-1 to inhibit FBG elevation in the development of diabetic mice. The abundance of unclassified Oscillospiraceae and the level of GLP-1 were both found to be up-regulated in diabetic rats with pectic polysaccharide intervention [36]. Furthermore, compared with the DC group, the Ord-TPS and PCSe-TPS intervention up-regulated the relative abundance of unclassified_[Eubacterium]_coprostanoligenes_group, unclassified_Lachnospiraceae, and Allobaculum, while Ord-TPS+Se intervention decreased the relative abundance of Allobaculum.…”

Section: Discussionmentioning

confidence: 91%

Protective Effects of Different Selenium Green Tea Polysaccharides on the Development of Type 2 Diabetes in Mice

Gao,

Zheng,

Wang

et al. 2023

Foods

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Selenium polysaccharides have attracted significant interest due to their superior function to that of individual polysaccharides. However, limited research has compared the protective effects of different selenium polysaccharides from different selenization methods on diabetes. This work aims to compare the preventive effects of natural selenium-enriched green tea polysaccharides (NSe-TPS), synthetic selenized green tea polysaccharides (PCSe-TPS), and a mixture of sodium selenite and green tea polysaccharides (ordinary tea polysaccharides (Ord-TPS)+Se) on the development of diabetes. While establishing a diabetes model induced by a high-sugar, high-fat diet combined with streptozotocin, different selenium polysaccharides were administered daily by gavage for nine weeks. Our findings indicate that PCSe-TPS exhibited superior preventive effects on developing type 2 diabetes compared to NSe-TPS and Ord-TPS+Se. PCSe-TPS effectively regulated glucose metabolism and insulin resistance by activating the PI3K/Akt pathway, thereby preventing elevated blood glucose levels. Additionally, PCSe-TPS mitigated oxidative damage and inflammatory responses in liver tissues. Notably, PCSe-TPS intervention reversed the decline in bacterial species richness and the abundance of unclassified_Oscillospiraceae during the development of diabetes in mice. These results provide valuable insights into the protective effects of PCSe-TPS against diabetes development, highlighting its advantages over NSe-TPS and Ord-TPS+Se.

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Section: Discussionmentioning

confidence: 91%

Protective Effects of Different Selenium Green Tea Polysaccharides on the Development of Type 2 Diabetes in Mice

Gao,

Zheng,

Wang

et al. 2023

Foods

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“…The results also demonstrated that Met-Met may improve intestinal health by increasing the abundance of beneficial bacteria. Additionally, the results of the ternary plot showed that Met-Met changed the bacterial diversity, whereas the LEfSe analysis revealed that the unique Roseburia [ 54 , 55 ], Lachnospiraceae_NK4A136_group [ 56 ], and unclassified_Oscillospiraceae [ 57 ] in the LFM group were beneficial bacteria. Roseburia was negatively correlated with MDA level and positively correlated with antioxidant enzymes, including SOD in the gut of mice [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

DL-Methionyl–DL-Methionine/DL-Methionine Supplementation Alleviated the Adverse Effects of Dietary Low Fishmeal Levels on Growth and Intestinal Health of Micropterus salmoides

Yu,

Masagounder,

Liang

et al. 2024

Antioxidants

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DL-methionyl–DL-methionine (AQUAVI® Met-Met) (Met-Met) (0.10%, 0.20%, 0.30%, and 0.40%) or DL-methionine (DL-Met) (0.10%, 0.20%, 0.30%, and 0.40%) were added to a low-fishmeal diet in an attempt to reduce fishmeal in the diet of Micropterus salmoides (M. salmoides). The fish were randomly allocated into ten experimental groups (n = 100), each with 4 replicates of 25 fish (16.39 ± 0.01 g) each. Compared to 25% FM, 0.40% of DL-Met and 0.10% of Met-Met promoted growth, and 0.10% of Met-Met decreased FCR. Compared to 25% FM, the supplementation of Met-Met or DL-Met improved the intestinal antioxidant capacity by upregulating the NF-E2-related factor 2-mediated antioxidant factors and enzyme activities and nuclear factor kappa-B-mediated anti-inflammatory factors while downregulating the pro-inflammatory factors, thereby exerting anti-inflammatory effects. Moreover, 0.10% of the Met-Met diet affected the Firmicutes-to-Bacteroidota ratio, increased the levels of Proteobacteria, changed the composition of intestinal flora (Roseburia, Lachnospiraceae_NK4A136_group, and unclassified_Oscillospiraceae), and enhanced intestinal dominant bacteria (Caldicoprobacter, Pseudogracilibacillus, and Parasutterella), leading to improved gut health. In summary, the supplementation of DL-Met or Met-Met alleviated the adverse effect of fishmeal reduction (from 40 to 25%) on the growth performance and intestinal health of M. salmoides.

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A novel Sagittaria sagittifolia L. polysaccharides mitigate DSS-induced colitis via modulation of gut microbiota and MAPK/NF-κB signaling pathways

Feng,

Chen,

Song

et al. 2024

International Journal of Biological Macromolecules

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Structural characterization of pectic polysaccharides from Amaranth caudatus leaves and the promotion effect on hippocampal glucagon-like peptide-1 level

Cited by 4 publications

References 63 publications

Protective Effects of Different Selenium Green Tea Polysaccharides on the Development of Type 2 Diabetes in Mice

Protective Effects of Different Selenium Green Tea Polysaccharides on the Development of Type 2 Diabetes in Mice

DL-Methionyl–DL-Methionine/DL-Methionine Supplementation Alleviated the Adverse Effects of Dietary Low Fishmeal Levels on Growth and Intestinal Health of Micropterus salmoides

A novel Sagittaria sagittifolia L. polysaccharides mitigate DSS-induced colitis via modulation of gut microbiota and MAPK/NF-κB signaling pathways

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