Structural characterization of n-hexadecanoic acid from the leaves of Ipomoea eriocarpa and its antioxidant and antibacterial activities

Ganesan, Theivanai; Murugesan, Subban; Leslee, Denzil Britto Christopher; Bharathi, K. Shanmuga; Seedevi, Palaniappan

doi:10.1007/s13399-022-03576-w

Cited by 42 publications

(18 citation statements)

References 39 publications

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“…More studies are investigating the antimicrobial properties of whole plant extracts and/or essential oils than pure compounds compounds 33 .Thus, in our study, we tested the dominant chemical compounds found in C. triumfettii as pure compounds, namely: germacrene D, aromadendrene, spathulenol, longifolene, linoleic acid, hexadecenoic acid, and a mixture of selected chemical compounds, however, none of these showed any significant inhibition of E. coli and S. epidermis growth. To our knowledge, these are the first results for these pure chemical compounds tested, except for hexadecenoic and linoleic acid 58 , 61 . Although some of the dominant components were very often correlated with the antimicrobial activity of the essential oil, and our statistical assessment of the literature data showed that some were strongly correlated with antimicrobial activity, we did not find experimental evidence for this statement.…”

Section: Resultsmentioning

confidence: 75%

“…Of the prominent compounds that have been correlated with good antimicrobial activity using both approaches: caryophyllene oxide, ß -caryophyllene, spathulenol, germacrene D, phytol, nonanal, decanal, hexadecanoic acid, heptacosane, nonacosane, pentacosane, tetracosane, tricosane, and benzyl benzoate, only some has been tested on some microbes as a pure compounds: caryophyllene oxide, ß -caryophyllene, phytol, hexadecanoic acid, and benzyl benzoate 52 – 58 .…”

Section: Resultsmentioning

confidence: 99%

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Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Carev

Gelemanović

Glumac

et al. 2023

Sci Rep

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The essential oils from the Centaurea genus are well known for their pharmacological properties. The most abundant and dominant chemical components in Centaurea essential oils are ß-caryophyllene, hexadecanoic acid, spathulenol, pentacosane, caryophyllene oxide, and phytol. However, whether these dominant components are the key drivers for observed antimicrobial activity remains unclear. Thus, the aim of this study was dual. Here we provide comprehensive, literature-based data to correlate the chemical compounds in Centaurea essential oils with the tested antimicrobial activity. Secondly, we characterized the essential oil of Centaurea triumfettii All. squarrose knapweed using coupled system gas chromatography–mass spectrometry and tested its phytochemicals for antimicrobial activity against E. coli and S. epidermis using disc diffusion assay and monitoring their growth in Muller Hinton broth. The most abundant compounds in C. triumfettii essential oil were hexadecanoic acid (11.1%), spathulenol (10.8%), longifolene (8.8%), germacrene D (8.4%), aromadendrene oxide (6.0%) and linoleic acid (5.3%). Based on our analysis of literature data from other Centaurea essential oils, they were positively correlated with antimicrobial activity. Using an agar disk diffusion method, tested chemical constituents did not show experimental evidence to support this positive correlation to antimicrobial activity when we tested them as pure components. The antibacterial effect of essential oil constituents may be related to a complex synergistic, rather than a single component as suggested by performed network pharmacology analysis, underlying the theoretical interactions between the essential oil phytochemicals listed as potentially responsible for antimicrobial activity and should be confirmed in further in-depth studies. This is the first report on the comparative analysis of Centaurea essential oils with good antimicrobial activity, as well as the first analysis of chemical components of the essential oil from C. triumfettii and the first report of antimicrobial activity of the representative, pure components: aromadendrene, germacrene D, spathulenol, longifolene, and the mixture of selected chemical compounds. This work contributes to the body of knowledge on the genus Centaurea and C. triumfettii species.

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Carev

Gelemanović

Glumac

et al. 2023

Sci Rep

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“…Similarly, the presence of these compounds in the BS-16 ethyl acetate extract could have disrupted the bacterial cell membrane. The antibacterial and antioxidant activity of n -hexadecanoic acid has been reported . In addition, n -hexadecanoic acid was found to have anti-inflammatory activity through inhibition of phospholipase A 2 activity .…”

Section: Discussionmentioning

confidence: 99%

Exploring Antibacterial Properties of Bioactive Compounds Isolated from Streptomyces sp. in Bamboo Rhizosphere Soil

Sriragavi,

Sangeetha,

Santhakumar

et al. 2023

ACS Omega

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The increasing concern over multidrug resistance in pathogens has led to an ongoing search for novel antibiotics derived from soil actinobacteria. In this current investigation, actinobacteria were isolated from the rhizosphere of bamboo plants collected within the Megamalai forest of the Western Ghats in the Theni zone of Tamil Nadu, India. These actinobacteria were subjected to characterization, and their growth conditions were optimized to enhance the production of bioactive compounds. To assess antibacterial properties, the isolated Actinobacteria underwent testing using the agar plug method. The strain exhibiting notable antibacterial activity underwent further characterization through 16s rRNA gene sequencing and subsequent phylogenetic analysis. Employing response surface methodology (RSM), cultural conditions were fine-tuned. Bioactive compounds were extracted from the culture medium using ethyl acetate, and their antibacterial and antioxidant effects were evaluated through disc diffusion and DPPH radical scavenging methods, respectively. Ethyl acetate extracts were analyzed by using FT-IR and GC–MS techniques. In total, nine strains of Actinobacteria were isolated from the rhizosphere soil of bamboo. Among these, strain BS-16 displayed remarkable antibacterial activity against three strains: Staphylococcus aureus (19 mm), Bacillus subtilis (12 mm), and Streptococcus pyogenes (10 mm). This strain was identified as Streptomyces sp. The optimal conditions for bioactive compound production were determined as follows: malt extract (10 g), yeast extract (5 g), dextrose (5 g), pH 6.5, and temperature 30 °C. After a 7-day incubation period, the results showed a 6% increase in production. The ethyl acetate fraction derived from strain BS-16 exhibited dose-dependent antibacterial and antioxidant activities. FT-IR and GC–MS analyses revealed the presence of active compounds with antibacterial effects within the extract. Consequently, further investigation into the BS-16 strain holds promise for scaling up the production of bioactive compounds possessing antibacterial and antioxidant properties.

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“…The efficacy of furan includes anti-cancer, antidepressant, anti-anxiolytic, anti-inflammatory, antimicrobial, etc., effects [22], which may reduce the anxiety symptoms of laying hens in a closed environment and increase the production performance due to the higher content of 2furyl-5-methyl furan in the fermented AAR. In addition, deoxyartemisinin, n-hexadecanoic acid, and aromandendrene have antimicrobial effects [23][24][25]. Phytol has antimicrobial, anxiolytic, anticonvulsant, anti-inflammatory, and immunomodulatory effects [26], while calarene also has anxiolytic and anticonvulsant effects.…”

Section: Discussionmentioning

confidence: 99%

Optimal Fermentation of Artemisia annua Residues and Its Effects on Production Performance of Laying Hens

Azad

et al. 2023

Fermentation

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Artemisia annua residue (ARR) is a pharmaceutical by-product produced after the extraction of artemisinin; it is rich in protein, crude fat, vitamins, trace elements, and bioactive compounds and contains negligible anti-nutritional factors. The present study aimed to optimize the fermentation conditions of ARR, evaluate the compound and microbial compositions of fermented AAR, and explore its effects on the production performance of laying hens. A total of 288 Xinyang black-feather laying hens were randomly allocated into four treatments for 30 days, including a control group (basal diet) and a basal diet supplemented with 1%, 2%, and 4% fermented AAR, respectively. The results showed that the optimized fermentation conditions of AAR were 80% moisture content, 3% inoculation quantity, 34 °C fermentation for 6 days, initial pH at 8, and 60 mesh (sieving). The compounds of 2-furyl-5-methyl furan, deoxyartemisinin, phytol, n-hexadecanoic acid, aromandendrene, and calarene had higher contents (average 6.86%) in the fermented AAR. The bacteria of Proteobacteria and Firmicutes (average 45.18%) were the most abundant phyla, and Acinetobacter, Bacillus, and Brevundimonas (average 15.87%) were the most abundant genera in the fermented AAR. The fungi of Phragmoplastophyta, Vertebrata, and Ascomycota (average 30.13%) were the most abundant phyla, and Magnoliophyta, Mammalia, Wickerhamomyces-Candida_clade, and Aspergillus were the most abundant genera (average 21.12%) in the fermented AAR. Furthermore, dietary supplementation of fermented AAR increased the average daily feed intake (ADFI), egg weight, and albumen height. Dietary supplementation of 2% and 4% fermented AAR increased the laying rate, while 2% fermented AAR increased the Haugh unit and decreased the feed-to-egg ratio. Collectively, it is concluded that fermented AAR has the potential to become a phytogenic feed additive, and dietary supplementation of 2% fermented AAR had better effects on the production performance of laying hens.

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Structural characterization of n-hexadecanoic acid from the leaves of Ipomoea eriocarpa and its antioxidant and antibacterial activities

Cited by 42 publications

References 39 publications

Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Exploring Antibacterial Properties of Bioactive Compounds Isolated from Streptomyces sp. in Bamboo Rhizosphere Soil

Optimal Fermentation of Artemisia annua Residues and Its Effects on Production Performance of Laying Hens

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