Structural Characterization of Mg-0.5Ca-xY Biodegradable Alloys

Istrate, Bogdan; Munteanu, Corneliu; Lupescu, Ștefan; Antoniac, Vasile Iulian; Şindilar, E. V.

doi:10.4028/www.scientific.net/kem.782.129

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Y-containing particles are typically of about 15 µm and appear in a brighter contrast than Mg 2 Ca lamellar intermetallic compounds. The surface morphological investigations of the present study add new information to some previous researches conducted by Istrate et al [ 57 ] in the case of Mg-based alloys having a Y concentration between 1.0 wt.% and 3.0 wt.%.…”

Section: Resultssupporting

confidence: 72%

“…Light microscopy analysis of the Mg-0.5Ca-xY: (a) Mg-0.5Ca-0.5Y; (b) Mg-0.5Ca-1.0Y[57]; (c) Mg-0.5Ca-1.5Y; (d) Mg-0.5Ca-2.0Y[57]; (e) Mg-0.5Ca-3.0Y[57].…”

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confidence: 99%

“…Surface SEM images of the Mg-0.5Ca-xY: (a) Mg-0.5Ca-0.5Y; (b) Mg-0.5Ca-1.0Y[57]; (c) Mg-0.5Ca-1.5Y; (d) Mg-0.5Ca-2.0Y[57]; (e) Mg-0.5Ca-3.0Y[57].Microstructural analysis highlights homogeneous structures with the formation of specific phases, namely α-Mg-based solid solution (α-Mg), Mg2Ca, and Mg24Y5. The Mg2Ca compound is…”

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confidence: 99%

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Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

et al. 2020

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In recent years, biodegradable Mg-based materials have been increasingly studied to be used in the medical industry and beyond. A way to improve biodegradability rate in sync with the healing process of the natural human bone is to alloy Mg with other biocompatible elements. The aim of this research was to improve biodegradability rate and biocompatibility of Mg-0.5Ca alloy through addition of Y in 0.5/1.0/1.5/2.0/3.0wt.%. To characterize the chemical composition and microstructure of experimental Mg alloys, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM), and X-ray diffraction (XRD) were used. The linear polarization resistance (LPR) method was used to calculate corrosion rate as a measure of biodegradability rate. The cytocompatibility was evaluated by MTT assay (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide) and fluorescence microscopy. Depending on chemical composition, the dendritic α-Mg solid solution, as well as lamellar Mg2Ca and Mg24Y5 intermetallic compounds were found. The lower biodegradability rates were found for Mg-0.5Ca-2.0Y and Mg-0.5Ca-3.0Y which have correlated with values of cell viability. The addition of 2–3 wt.%Y in the Mg-0.5Ca alloy improved both the biodegradability rate and cytocompatibility behavior.

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Section: Resultssupporting

confidence: 72%

“…Light microscopy analysis of the Mg-0.5Ca-xY: (a) Mg-0.5Ca-0.5Y; (b) Mg-0.5Ca-1.0Y[57]; (c) Mg-0.5Ca-1.5Y; (d) Mg-0.5Ca-2.0Y[57]; (e) Mg-0.5Ca-3.0Y[57].…”

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Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

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“…The WE43 alloy contains Y, Zr, and RE, and it exhibits a very good creep resistance and stability of the mechanical properties at high temperatures. In industrial practice, the Mg-based alloys have an increased hardness when rare earth metals are used [ 65 ]. In Table 5 , the mechanical properties of Mg-based alloys, which do not contain aluminum, are presented.…”

Section: Attributes Of Mg Alloys For Temporary Orthopedic Implantsmentioning

confidence: 99%

Magnesium-Based Alloys Used in Orthopedic Surgery

et al. 2022

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Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval.

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“…Each alloying element is essential because some of them help to increase mechanical properties and corrosion resistance [ 61 , 62 ]. Higher biocompatibility and osteoconductivity can be achieved [ 63 , 64 ]. MgYREZr is the first approved material dedicated for clinical use in pediatric orthopedic surgery.…”

Section: Biocompatible Implants Used In Pediatric Osteochondral Fract...mentioning

confidence: 99%

Treatment of Knee Osteochondral Fractures

et al. 2022

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Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. When considering this, the term osteochondral fracture is preserved only for an osteochondral defect that combines disruption of the articular cartilage and subchondral bone. These fractures commonly occur after sports practice and are associated with acute lateral patellar dislocations. Many of these lesions are initially diagnosed by plain radiographs; however, a computed tomography (CT) scan or magnetic resonance imaging (MRI) can add significant value to the diagnosis and treatment. Treatment methods may vary depending on the location and size of the fracture, fragment instability, and skeletal maturity. The paper reports a 14-year-old boy case with an osteochondral fracture due to sports trauma. The medical approach involved an arthrotomy of the knee, drainage of the hematoma, two Kirschner wires (K-wires) for temporary fixation to restructure anatomic alignment, and a titanium Herbert screw fixing the fracture permanently. The patient had a favorable postoperative outcome with no residual pain, adequate knee stability, and a normal range of motion. The mobility of the knee was fully recovered.

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Structural Characterization of Mg-0.5Ca-xY Biodegradable Alloys

Cited by 7 publications

References 19 publications

Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

Magnesium-Based Alloys Used in Orthopedic Surgery

Treatment of Knee Osteochondral Fractures

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